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    杨道良, 严文佳, 朱云程, 吴彦, 季卫东, 陈玄玄. 阿立哌唑治疗经典与非经典抗精神病药物所致高泌乳素血症的随机对照研究[J]. 蚌埠医科大学学报, 2020, 45(1): 44-47. DOI: 10.13898/j.cnki.issn.1000-2200.2020.01.011
    引用本文: 杨道良, 严文佳, 朱云程, 吴彦, 季卫东, 陈玄玄. 阿立哌唑治疗经典与非经典抗精神病药物所致高泌乳素血症的随机对照研究[J]. 蚌埠医科大学学报, 2020, 45(1): 44-47. DOI: 10.13898/j.cnki.issn.1000-2200.2020.01.011
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    YANG Dao-liang, YAN Wen-jia, ZHU Yun-cheng, WU Yan, JI Wei-dong, CHEN Xuan-xuan. A randomized controlled trial on aripiprazole in the treatment of hyperprolactinemia induced by typical or atypical antipsychotics[J]. Journal of Bengbu Medical University, 2020, 45(1): 44-47. DOI: 10.13898/j.cnki.issn.1000-2200.2020.01.011
    Citation: YANG Dao-liang, YAN Wen-jia, ZHU Yun-cheng, WU Yan, JI Wei-dong, CHEN Xuan-xuan. A randomized controlled trial on aripiprazole in the treatment of hyperprolactinemia induced by typical or atypical antipsychotics[J]. Journal of Bengbu Medical University, 2020, 45(1): 44-47. DOI: 10.13898/j.cnki.issn.1000-2200.2020.01.011
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    阿立哌唑治疗经典与非经典抗精神病药物所致高泌乳素血症的随机对照研究

    A randomized controlled trial on aripiprazole in the treatment of hyperprolactinemia induced by typical or atypical antipsychotics

      摘要
    • 摘要:
      目的探讨阿立哌唑治疗经典与非经典抗精神病药物所致高泌乳素血症的疗效及安全性。
      方法采取前瞻性开放性标签、随机、对照的研究设计，将120例服用经典（氯丙嗪）和非经典（利培酮）抗精神病药物后出现高泌乳素血症的精神分裂症病人，随机分为氯丙嗪合并阿立哌唑5 mg和阿立哌唑10 mg组（各30例），利培酮合并阿立哌唑5 mg和阿立哌唑10 mg组（各30例），总疗程12周。于治疗前、治疗后第4、8、12周分别检测催乳素；以阳性和阴性症状量表（PANSS）、副反应量表（TESS）评定对抗精神病药物疗效的影响及不良反应。
      结果4组干预前后血清泌乳素水平和PANSS总分评分比较，差异有统计学意义（P < 0.05），各时间点组间比较差异无统计学意义（P>0.05）。4组不良反应发生率比较差异无统计学意义（χ2=1.11，P>0.05）。
      结论小剂量（5 mg/d）阿立哌唑可以逆转经典和非经典抗精神病药物所致高催乳素血症，能辅助改善精神症状且不增加不良反应。

       

      Abstract:
      ObjectiveTo investigate the efficacy and safety of aripiprazole in the treatment of hyperprolactinemia induced by typical or atypical antipsychotics.
      MethodsAccording to the prospective open-label, randomized and controlled study, 120 schizophrenic patients with hyperprolactinaemia caused by typical (chlorpromazine) or atypical antipsychotics (risperidone) were randomly divided into the chlorpromazine combined with aripiprazole groups (5 mg or 10 mg by oral), and risperidone combined with aripiprazole groups (5 mg or 10 mg by oral) (30 cases in each group), and the total treatment period was 12 weeks.The levels of prolactin before treatment and after 4, 8 and 12 weeks of treatment were detected.The efficacy and adverse reactions of antipsychotics were evaluated using positive and negative symptom scale (PANSS) and side effect scale (TESS).
      ResultsThe differences of the serum levels of prolactin and PANSS scores among four groups before intervention were not statistically significant (P>0.05), and there was no statistical significance in the serum levels of prolactin and PANSS scores at all time-points (P>0.05).The differences of the incidence rates of adverse reaction among four groups were not statistically significant (P>0.05).
      ConclusionsLow-dose aripiprazole can reverse the hyperprolactin induced by typical and atypical antipsychotics, improve the psychotic symptoms, and does not increase adverse event.

       

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