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    黄显元, 游荔. 2型糖尿病合并冠心病病人血清超敏C反应蛋白、肿瘤坏死因子-α、高迁移率蛋白B1水平变化及临床意义[J]. 蚌埠医科大学学报, 2020, 45(1): 48-50, 56. DOI: 10.13898/j.cnki.issn.1000-2200.2020.01.012
    引用本文: 黄显元, 游荔. 2型糖尿病合并冠心病病人血清超敏C反应蛋白、肿瘤坏死因子-α、高迁移率蛋白B1水平变化及临床意义[J]. 蚌埠医科大学学报, 2020, 45(1): 48-50, 56. DOI: 10.13898/j.cnki.issn.1000-2200.2020.01.012
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    HUANG Xian-yuan, YOU Li. Changes of the serum levels of hs-CRP, TNF-α and HMGB1 in patients with type 2 diabetes mellitus complicated with coronary heart disease, and its clinical diagnosis value[J]. Journal of Bengbu Medical University, 2020, 45(1): 48-50, 56. DOI: 10.13898/j.cnki.issn.1000-2200.2020.01.012
    Citation: HUANG Xian-yuan, YOU Li. Changes of the serum levels of hs-CRP, TNF-α and HMGB1 in patients with type 2 diabetes mellitus complicated with coronary heart disease, and its clinical diagnosis value[J]. Journal of Bengbu Medical University, 2020, 45(1): 48-50, 56. DOI: 10.13898/j.cnki.issn.1000-2200.2020.01.012
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    2型糖尿病合并冠心病病人血清超敏C反应蛋白、肿瘤坏死因子-α、高迁移率蛋白B1水平变化及临床意义

    Changes of the serum levels of hs-CRP, TNF-α and HMGB1 in patients with type 2 diabetes mellitus complicated with coronary heart disease, and its clinical diagnosis value

      摘要
    • 摘要:
      目的探讨2型糖尿病合并冠心病病人的血清肿瘤坏死因子-α（TNF-α）、超敏C反应蛋白（hs-CRP）以及高迁移率蛋白B1（HMGB1）水平变化的相关性以及临床诊断意义。
      方法选择单纯2型糖尿病病人32例（A组），单纯冠心病病人38例（B组），糖尿病合并冠心病病人40例（C组），以及45名健康体检者作为健康对照组。采用ELISA法以及散射速率比浊法对病人的TNF-α、hs-CRP以及HMGB1表达水平进行检测。
      结果各组间血清hs-CRP、TNF-α和HMGB1水平差异均有统计学意义（P < 0.01），其中C组显著高于B组，B组显著高于A组，A组显著高于健康对照组（P < 0.01）。随着冠状动脉病变支数增加，C组病人的血清TNF-α、hs-CRP、HMGB1表达水平升高，单支病变组和双支病变组病人的TNF-α、hs-CRP和HMGB1水平差异均无统计学意义（P>0.05），其余各组病人各指标之间差异均有统计学意义（P < 0.01）。治疗后，血清空腹血糖水平和hs-CRP与TNF-α呈正相关（P < 0.01）；血清HMGB1水平和Hs-CRP与TNF-α呈正相关（P < 0.05）；Gensini积分和血清HMGB1水平呈正相关（P < 0.05）。
      结论TNF-α、hs-CRP以及HMGB1均参与了2型糖尿病合并冠心病病人动脉粥样硬化的发生以及发展，3个指标的水平表达对病人的病情监测以及治疗具有指导意义。

       

      Abstract:
      ObjectiveTo investigate the changes of the serum levels of tumor necrosis factor-α (TNF-α), hypersensitive Creactive protein (hs-CRP) and high mobility protein B1 (HMGB1) in patients with type 2 diabetes mellitus complicated with coronary heart disease, and its clinical significance.
      MethodsThirty-two patients with type 2 diabetes mellitus, 38 patients with coronary artery disease, 40 patients with type 2 diabetes mellitus complicated with coronary artery disease, and 40 healthy examiners were divided into group A, group B, group C and control group, respectively.The levels of TNF-α, hs-CRP and HMGB1 were measured by ELISA and scatter turbidimetric method.
      ResultsThe differences of the serum levels of hs-CRP, TNF-α and HMGB1 among four groups were statistically significant (P < 0.01), which in group C was significantly higher than that in group B, which in group B was significantly higher than that in group A, and which in group A was significantly higher than that in control group (P < 0.01).With the number of coronary artery lesions increasing, the serum levels of TNF-α, hs-CRP and HMGB1 increased, the differences of the serum levels of TNF-α, hs-CRP and HMGB1 between single-branch lesion group and double-branch lesion group were not statistically significant (P>0.05), and the differences of various indexes among other groups were statistically significant (P < 0.01).After treatment, the serum level of FPG was positively correlated with hs-CRP and TNF-α levels (P < 0.01), the serum levels of HMGB1 and hs-CRP were positively correlated with TNF-α level (P < 0.05), and the Gensini score was positively correlated with the serum level of HMGB1 (P < 0.05).
      ConclusionsTNF-α, hs-CRP and HMGB1 are all involved in the occurrence and development of atherosclerosis in patients with type 2 diabetes mellitus complicated with coronary heart disease.The expression levels of three indicators have guiding significance in the diagnosis of disease and treatment of patients.

       

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