殷发祥, 钱军. 浸润性乳腺癌及不同分子分型病人的血脂水平分析[J]. 蚌埠医学院学报, 2020, 45(1): 81-84. DOI: 10.13898/j.cnki.issn.1000-2200.2020.01.021
    引用本文: 殷发祥, 钱军. 浸润性乳腺癌及不同分子分型病人的血脂水平分析[J]. 蚌埠医学院学报, 2020, 45(1): 81-84. DOI: 10.13898/j.cnki.issn.1000-2200.2020.01.021
    YIN Fa-xiang, QIAN Jun. Analysis of the serum lipid levels in patients with invasive breast cancer and different molecular classifications[J]. Journal of Bengbu Medical College, 2020, 45(1): 81-84. DOI: 10.13898/j.cnki.issn.1000-2200.2020.01.021
    Citation: YIN Fa-xiang, QIAN Jun. Analysis of the serum lipid levels in patients with invasive breast cancer and different molecular classifications[J]. Journal of Bengbu Medical College, 2020, 45(1): 81-84. DOI: 10.13898/j.cnki.issn.1000-2200.2020.01.021

    浸润性乳腺癌及不同分子分型病人的血脂水平分析

    Analysis of the serum lipid levels in patients with invasive breast cancer and different molecular classifications

    • 摘要:
      目的比较良性乳腺疾病病人和浸润性乳腺癌病人之间及激素受体(HR)阳性和人类表皮生长因子受体2(HER-2)阳性乳腺癌病人之间的血脂水平差异,分析血脂水平与乳腺癌发生发展的相关性。
      方法选取初诊为浸润性乳腺癌的100例病人为观察组,其中HR阳性50例,HER-2阳性50例;另外选取同期住院治疗的与其一般资料相匹配的100例良性乳腺疾病病人作为对照组,检验所有对象血浆总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C)水平,分析血脂代谢水平与浸润性乳腺癌之间的关系,同时进一步探讨HR阳性乳腺癌病人和HER-2阳性乳腺癌病人之间的血脂差异。
      结果观察组病人血清TC、TG、LDL-C水平明显高于对照组(P < 0.05~P < 0.01),HDL-C水平明显低于对照组(P < 0.01)。按是否绝经分层分析发现,除LDL-C水平外,其他结果差异均有统计学意义。HER-2阳性乳腺癌病人TC、TG、LDL-C水平明显高于HR阳性乳腺癌病人(P < 0.05),HDL-C水平明显低于HR阳性乳腺癌(P < 0.05)。
      结论女性血脂水平和乳腺癌患病风险之间存在一定的关联,高TC、TG、LDL-C和低HDL-C水平可能与乳腺癌发生、发展及分子分型存在着一定关系,提示脂质分析是乳腺癌分子分型研究的新方向。

       

      Abstract:
      ObjectiveTo compare the serum lipid level between patients with benign breast disease and invasive breast cancer, and between positive hormone receptor (HR) and human epidermal growth factor receptor-2 (HER-2) -positive patients, and analyze the correlation between the level of lipid, and occurrence and development of breast cancer.
      MethodsOne hundred patients with invasive breast cancer (including 50 cases with HR-positive and 50 cases with HER-2-positive) and 100 patients with benign breast disease were divided into the observation group and control group, respectively.The levels of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) in two groups were detected, the relationship between the level of serum lipid and invasive breast cancer was analyzed, and the difference of the blood lipid level between HR-positive and HER-2-positive breast cancer patients was analyzed.
      ResultsThe serum levels of TC, TG and LDL-C in observation group were significantly higher than those in control group (P < 0.05 to P < 0.01), and the HDL-C level in observation group was significantly lower than that in control group (P < 0.01).According to the stratified analysis of pre-menopause and post-menopause, except for the LDL-C, the differences of other indicators were statistically significant (P < 0.05).The levels of TC, TG and LDL-C in HER-2-positive breast cancer patients were significantly higher than those in HR-positive patients (P < 0.05), and the level of HDL-C in HER-2-positive breast cancer patients was significantly lower than that in HR-positive patients (P < 0.05).
      ConclusionsThere is a certain correlation between serum lipid level and breast cancer risk for women.The high levels of TC, TG, LDL-C and low level of HDL-C may be related to the occurrence, development and molecular classifications of breast cancer, which suggests that the lipid analysis is a new direction of molecular classifications.

       

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