ObjectiveTo analyze the relationship between human papillomavirus (HPV) infection, and vaginal microecology and inflammatory reaction.

MethodsOne hudred and eighty-two patients with HPV infection complicated with negative cervical cytology and 160 patients with negative HPV complicated with negative cervical cytology were divided into the infection group and control group, respectively.The vaginal microecology and inflammatory response were compared between two groups.The relationship between HPV infection, and vaginal microecology and inflammatory response was analyzed using logistic regression analysis.

ResultsThe differences of the proportion of leukocytes >10/HPF, and levels of tumor necrosis factor-α, interleukin-6 (IL-6) and IL-10 between two groups were not statistically significant (P>0.05).The bacterial vaginosis, vaginal candidiasis, positive aerobic vaginitis, pH>4.5, lactobacillus reduction ratio and IL-4 level in infection group were higher than those in control group (P < 0.05 to P < 0.01).The levels of IL -2, IFN-γ, IFN-γ/IL-4 and IL-2/IL-4 in infection group were lower than those in control group (P < 0.05 to P < 0.01).The results of logistic regression analysis showed that the bacterial vaginal disease, vaginal candidiasis and aerobic vaginitis, pH, lactobacilli, IL-2, IFN-γ, IFN-γ/IL-4, IL-2/IL-4 were closely related to the HPV infection (P < 0.05 to P < 0.01).

ConclusionsThe HPV infection is closely related to vaginal microecology and inflammatory reaction, which should be clinically paid attention to.