丁虎. 血清维生素D结合蛋白对急性胰腺炎的预警效应及其变化机制研究[J]. 蚌埠医学院学报, 2020, 45(2): 204-206. DOI: 10.13898/j.cnki.issn.1000-2200.2020.02.018
    引用本文: 丁虎. 血清维生素D结合蛋白对急性胰腺炎的预警效应及其变化机制研究[J]. 蚌埠医学院学报, 2020, 45(2): 204-206. DOI: 10.13898/j.cnki.issn.1000-2200.2020.02.018
    DING Hu. Study on the early warning effect of serum vitamin D binding protein in acute pancreatitis, and its mechanism[J]. Journal of Bengbu Medical College, 2020, 45(2): 204-206. DOI: 10.13898/j.cnki.issn.1000-2200.2020.02.018
    Citation: DING Hu. Study on the early warning effect of serum vitamin D binding protein in acute pancreatitis, and its mechanism[J]. Journal of Bengbu Medical College, 2020, 45(2): 204-206. DOI: 10.13898/j.cnki.issn.1000-2200.2020.02.018

    血清维生素D结合蛋白对急性胰腺炎的预警效应及其变化机制研究

    Study on the early warning effect of serum vitamin D binding protein in acute pancreatitis, and its mechanism

    • 摘要:
      目的:分析血清维生素D结合蛋白(DPB)在急性胰腺炎病人治疗过程中的预警效应,分析其产生相应变化的可能机制,为临床急性胰腺炎病人治疗方案的完善提供参考。
      方法:急性胰腺炎病人86例,根据就诊时病情严重程度分为轻度组31例、中度组30例和重度组25例,选取同期健康检查者30名为对照组,比较4组病人就诊后不同时间段的DPB。随着病人病情的发展,对重度胰腺炎或者轻、中度转变为重度急性胰腺炎病人,采用改良Marshall评分系统评价器官功能衰竭程度,比较不同评分病人的DPB水平。
      结果:急性胰腺炎病人中,重度组病人DBP水平低于对照组(P < 0.05),轻度组和中度组病人DBP水平与对照组差异均无统计学意义(P>0.05)。轻度组病人治疗1周、2周后DBP水平均高于治疗前(P < 0.05和P < 0.01);中、重度组病人治疗2周后DBP水平均高于治疗前(P < 0.05)。Marshall评分3~4分病人治疗2周后的DBP水平均高于Marshall评分0分病人(P < 0.05)。
      结论:急性胰腺炎病人血清DPB水平与病人病情发展存在一定关联,具有一定预警作用和进一步研究的临床价值。

       

      Abstract:
      ObjectiveTo analyze the early warning effects of serum vitamin D binding protein(DPB) during the treatment of acute pancreatitis, analyze the possible mechanism for providing a reference in the improvement of acute pancreatitis treatment regimen.
      MethodsEighty-six acute pancreatitis patients were divided into the mild group(31 cases), moderate group(30 cases) and severe group(25 case) according to the severity of disease at the time of visit, and 30 healthy people was set as the control group.The DPB at different time periods after treatment were compared among four groups.The degree of organ failure in severe pancreatitis patients or mild and moderate transforming into severe acute pancreatitis patients were evaluated using modified Marshall scoring system, and the DPB levels in different scores patients were compared.
      ResultsAmong the acute pancreatitis patients, the DPB level in severe group was significantly lower than that in control group(P < 0.05), and the differences of the DBP levels between the mild and moderate groups, and control group were not statistically significant(P>0.05).The levels of DBP in mild group after 1 and 2 weeks of treatment were higher than that before treatment(P < 0.05 and P < 0.01), and the levels of DBP in moderate and severe groups after 2 weeks of treatment were higher than that before treatment(P < 0.05).The DBP level of patients with Marshall scores 3-4 after 2 weeks of treatment was higher than that of patients with Marshall score 0(P < 0.05).
      ConclusionsThe serum level of DPB in acute pancreatitis patients is related to the disease progression, which plays certain role in early warning and has clinical value for further research.

       

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