王林, 刘君, 李天成. 负压封闭引流技术结合表皮生长因子治疗深度烧伤病人效果[J]. 蚌埠医学院学报, 2020, 45(2): 223-226. DOI: 10.13898/j.cnki.issn.1000-2200.2020.02.023
    引用本文: 王林, 刘君, 李天成. 负压封闭引流技术结合表皮生长因子治疗深度烧伤病人效果[J]. 蚌埠医学院学报, 2020, 45(2): 223-226. DOI: 10.13898/j.cnki.issn.1000-2200.2020.02.023
    WANG Lin, LIU Jun, LI Tian-cheng. Effect of vacuum sealing drainage technique combined with epidermal growth factor in the treatment of deep burn[J]. Journal of Bengbu Medical College, 2020, 45(2): 223-226. DOI: 10.13898/j.cnki.issn.1000-2200.2020.02.023
    Citation: WANG Lin, LIU Jun, LI Tian-cheng. Effect of vacuum sealing drainage technique combined with epidermal growth factor in the treatment of deep burn[J]. Journal of Bengbu Medical College, 2020, 45(2): 223-226. DOI: 10.13898/j.cnki.issn.1000-2200.2020.02.023

    负压封闭引流技术结合表皮生长因子治疗深度烧伤病人效果

    Effect of vacuum sealing drainage technique combined with epidermal growth factor in the treatment of deep burn

    • 摘要:
      目的探讨负压封闭引流(VSD)技术结合表皮生长因子治疗深度烧伤病人效果。
      方法选取100例Ⅱ度烧伤病人,按照随机数字表法分为对照组和观察组,每组50例。2组病人创面清洗完成后,采用VSD装置对创面进行封闭,对照组采用0.9%氯化钠注射液,观察组采用表皮生长因子溶液冲洗吸引装置及病人的创面。比较2组病人的创面愈合情况和炎症应激反应情况。
      结果治疗5 d后,2组创面愈合率差异无统计学意义(P>0.05),观察组的白细胞介素-1和肿瘤坏死因子-α、去甲肾上腺素、肾上腺素、肾素均显著低于对照组(P < 0.01)。治疗10 d、15 d后2组创面愈合率均显著升高,且观察组高于对照组(P < 0.05)。观察组创面愈合时间、瘢痕愈合数及感染数均低于对照组(P < 0.05~ P < 0.01)。
      结论VSD技术结合表皮生长因子能促进深度烧伤病人的创面愈合,减轻病人的炎症应激反应,值得临床推广。

       

      Abstract:
      ObjectiveTo investigate the effects of vacuum sealing drainage(VSD) technique combined with epidermal growth factor(EGF) in the treatment of deep burn.
      MethodsOne hundred patients with deep burn were randomly divided into the control group and observation group(50 cases each group).The wound in two groups was cleaned, and closed with VSD device.The control group was treated with normal saline, and the observation group was treated with EGF solution washing suction device.The wound healing and inflammatory reaction condition were compared between two groups.
      ResultsAfter 5 d of treatment, there was no statistical significance in the wound healing rate between two groups(P>0.05), and the levels of interleukin-1 and tumor necrosis factor-α, noradrenaline, epinephrine and rennin in observation group were significantly lower than those in control group(P < 0.01).The wound healing rates in two groups significantly increased after 10 d and 15 d of treatment, and which in observation group was higher than that in control group(P < 0.05).The wound healing time, number of scar healing cases and infection cases in observation group were significantly lower than those in control group(P < 0.05 to P < 0.01).
      ConclusionsVSD technique combined with EGF can promote the wound healing in patients with deep burn, improve the healing effect, reduce the patient's inflammatory stress reaction, which is worthy of clinical promotion.

       

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