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    吴凤, 李阳, 张艳, 成立, 孙医学. 彩色脉搏波技术定量评价Graves病早期颈动脉结构及功能变化[J]. 蚌埠医科大学学报, 2020, 45(2): 235-237. DOI: 10.13898/j.cnki.issn.1000-2200.2020.02.027
    引用本文: 吴凤, 李阳, 张艳, 成立, 孙医学. 彩色脉搏波技术定量评价Graves病早期颈动脉结构及功能变化[J]. 蚌埠医科大学学报, 2020, 45(2): 235-237. DOI: 10.13898/j.cnki.issn.1000-2200.2020.02.027
    shu
    WU Feng, LI Yang, ZHANG Yan, CHENG Li, SUN Yi-xue. Application value of UFPWV in quantitative evaluating the early changes of carotid artery structure and function in patients with Graves disease[J]. Journal of Bengbu Medical University, 2020, 45(2): 235-237. DOI: 10.13898/j.cnki.issn.1000-2200.2020.02.027
    Citation: WU Feng, LI Yang, ZHANG Yan, CHENG Li, SUN Yi-xue. Application value of UFPWV in quantitative evaluating the early changes of carotid artery structure and function in patients with Graves disease[J]. Journal of Bengbu Medical University, 2020, 45(2): 235-237. DOI: 10.13898/j.cnki.issn.1000-2200.2020.02.027
    shu

    彩色脉搏波技术定量评价Graves病早期颈动脉结构及功能变化

    Application value of UFPWV in quantitative evaluating the early changes of carotid artery structure and function in patients with Graves disease

      摘要
    • 摘要:
      目的应用彩色脉搏波技术（ultrafast pulse wave velocity，UFPWV）定量评价Graves病（Graves disease，GD）病人早期颈动脉结构和功能变化。
      方法选取内-中膜厚度（intima-medium thickness，IMT）未增厚GD病人76例（GD组），同期健康体检成人76名作为对照组，测量2组受试者颈动脉IMT，采用UFPWV采集脉搏波传导速度，包括收缩期开始时脉搏波传导速度（beginning of systole，BS）和收缩期结束脉搏波传导速度（end of systole，ES），比较相关参数，分析BS、ES与IMT、甲状腺容积及血清甲状腺激素水平的相关性。
      结果GD组颈总动脉IMT与对照组差异无统计学意义（P>0.05），BS及ES均明显高于对照组（P < 0.01）。GD病人血管弹性参数BS、ES与甲状腺体积均无明显相关性（P>0.05），但均与IMT呈明显正相关关系（P < 0.01），ES与游离三碘甲状原氨酸水平亦呈正相关关系（P < 0.01）。
      结论UFPWV可发现GD病人颈动脉IMT增厚以前的早期弹性变化，可作为评价GD病人动脉弹性的新型有效手段。

       

      Abstract:
      ObjectiveTo explore the application value of ultrafast pulse wave velocity(UFPWV) in quantitative evaluating the early changes of carotid artery structure and function in patients with Graves disease(GD).
      MethodsSeventy-six GD patients without intima-media thickness(IMT) of carotid artery thickening and 76 healthy people were divided into the GD group and control group, respectively.The carotid IMT in two groups was measured.The pulse wave conduction velocity was recorded using the UFPWV technology, and which included the pulse wave conduction velocity at the beginning and end of systole(BS and ES).The related parameters were compared, and the correlation of BS and ES with IMT, thyroid volume and serum thyroid hormone level were analyzed.
      ResultsThere was no statistical significance in IMT between GD group and control group(P>0.05), and the BS and ES in GD group were significantly higher than those in control group(P < 0.01).The BS and ES of vascular elasticity parameters were not correlated with the thyroid volume(P>0.05), but were positively correlated with IMT(P < 0.01).The ES was positively correlated with the level of free triiodothyronine.
      ConclusionsThe early changes of carotid artery elasticity in patients with GD before IMT thickening can be detected by UFPWV, which can be used as a new effective method to evaluate the artery elasticity in patients with GD.

       

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