原发性肝癌病人血清高尔基蛋白73、铁蛋白、甲胎蛋白联合检测的早期诊断价值分析

赵惠柳; 舒宏; 欧超; 吴君荣; 李艳秋; 任宁毅; 雷考宁; 李佳文; 朱波

doi:10.13898/j.cnki.issn.1000-2200.2020.02.030

原发性肝癌病人血清高尔基蛋白73、铁蛋白、甲胎蛋白联合检测的早期诊断价值分析

Significance of the combined detection of serum Golgi protein 73, serum ferritin and α-fetoprotein in patients with primary hepatocellular carcinoma

摘要

摘要:
目的分析原发性肝癌病人早期经血清高尔基蛋白73（GP73）、铁蛋白（SF）、甲胎蛋白（AFP）联合检测的诊断价值。
方法选取原发性肝癌病人72例作为观察组，同期选取健康体检人员60名作为对照组。检测2组受试者GP73、SF、AFP三项指标，对三项指标与原发性肝癌发病的相关性作logistic回归分析，比较三种指标单独及联合检测原发性肝癌的敏感性与特异性。
结果观察组病人GP73、SF、AFP指标均明显高于对照组（P < 0.01）。回归分析结果显示，GP73、SF、AFP水平高均为原发性肝癌的危险因素（P < 0.05~P < 0.01）。GP73、SF、AFP指标单独检测诊断原发性肝癌的敏感性分别为69.44%、66.67%、70.83%，特异性分别为96.67%、91.67%、95.00%。三项联合检测的敏感性为98.61%，高于单独检测；特异性为83.33%，低于单独检测。
结论GP73、SF、AFP是临床诊断原发性肝癌的重要血清学指标，与单项检测相比，三项联合检测提高了诊断敏感性。

Abstract:
ObjectiveTo analyze the diagnosis value of the combined detection of Golgi protein 73(GP73), serum ferritin(SF) and α-fetoprotein(AFP) in patients with primary hepatocellular carcinoma.
MethodsSeventy-two patients with primary hepatocellular carcinoma and 60 healthy people were divided into the observation group and control group, respectively.The levels of GP73, SF and AFP in two groups were detected, the correlation among three indexes and incidence of primary hepatocellular carcinoma was analyzed using logistic regression analysis.The sensitivity and specificity of separate and combinde detection of three indexes were compared.
ResultsThe levels of GP73, SF and AFP in observation group were significantly higher than those in control group(P < 0.01).The results of regression analysis showed that high levels of GP73, SF and AFP were the risk factors of primary hepatocellular carcinoma(P < 0.05 to P < 0.01).The sensitivity and specificity of GP73, SF and AFP in detecting primary hepatocellular carcinoma were(69.44%, 66.67% and 70.83%) and(96.67%, 91.67% and 95.00%), respectively.The sensitivity and specificity of the combined detection were 98.61% and 83.33%, respectively, which was higher and lower than that in alone index detection, respectively.
ConclusionsGP73, SF and AFP are important serological markers in the diagnosis of primary hepatocellular carcinoma.The combined detection of GP73, SF and AFP significantly improve the sensitivity and specificity of diagnosis compared with the alone index detection.

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