BRAFV600E基因突变与甲状腺乳头状癌中央区淋巴结转移的关系

Study on the relationship between BRAFV600E mutation and central lymph node metastasis of papillary thyroid carcinoma

摘要:
目的分析BRAFV600E基因突变与甲状腺乳头状癌（PTC）中央区淋巴结（CLN）转移的关系，探讨CLN转移的危险因素。
方法检测104例PTC病例BRAFV600E基因突变情况，分析该突变与PTC临床病理特征、超声特征的关系，单因素及多因素分析CLN转移的危险因素。
结果BRAFV600E基因突变与肿瘤最大径、肿瘤钙化、被膜外侵犯及CLN转移相关（P < 0.01），BRAFV600E基因突变和被膜外侵犯是CLN转移的独立因素（P < 0.01）。
结论BRAFV600E基因突变可为PTC手术CLN清扫提供基因依据。

Abstract:
ObjectiveTo analyze the relationship between BRAFV600E mutation and central lymph node(CLN) metastasis of thyroid papillary carcinoma(PTC), and predict the risk factors of CLN metastasis.
MethodsThe BRAFV600E mutation was detected in 104 PTC cases, and the relationships between the mutation and clinicopathological, ultrasonic characteristics of PTC were analyzed.The risk factors of CLN metastasis were analyzed using single factor and multiple factors methods.
ResultsBRAFV600E mutation was associated with the maximum diameter of tumor, tumor calcification, extramembrane invasion and CLN metastasis(P < 0.01).The BRAFV600E mutation and extramembrane invasion were the independent factors of CLN metastasis(P < 0.01).
ConclusionsBRAFV600E mutation can provide the genetic basis for CLN dissection in PTC surgery.