D-二聚体、C反应蛋白及白细胞介素-6在新型冠状病毒肺炎的临床意义及相关性分析

袁娜娜; 韩明锋; 腾小宝; 时靖峰

doi:10.13898/j.cnki.issn.1000-2200.2020.06.002

D-二聚体、C反应蛋白及白细胞介素-6在新型冠状病毒肺炎的临床意义及相关性分析

Analysis of clinical significance and correlation of D-dimer, C reactive protein and interleukin-6 in COVID-19

摘要

摘要:
目的探讨血清D-二聚体、C反应蛋白（C reactive protein，CRP）、白细胞介素-6（interleukin-6，IL-6）在新型冠状病毒肺炎（corona virus disease 2019，COVID-19）病人的临床意义及相关性分析。
方法回顾性分析COVID-19确诊病人128例，根据临床分型分为普通型组（102例）、重型组（22例）和危重型组（4例），选取90例非COVID-19且非重症的社区获得性肺炎病人作为对照组，比较对照组和普通型组血清D-二聚体、CRP及IL-6的水平，比较普通型组、重症组和危重症组血清D-二聚体、CRP及IL-6的水平，分析COVID-19病人血清D-二聚体与CRP、IL-6的相关性。
结果普通型组血清D-二聚体和CRP水平均低于对照组（P < 0.05），2组血清IL-6水平比较差异无统计学意义（P>0.05）。普通型、重型及危重型COVID-19病人血清D-二聚体、CRP及IL-6水平比较差异有统计学意义（P < 0.01）。其中重型组和危重型组的血清D-二聚体、CRP及IL-6水平均高于普通型组（P < 0.05）。COVID-19病人中D-二聚体水平与CRP及IL-6水平均呈正相关（P < 0.01）。
结论血清D-二聚体、CRP及IL-6水平有助于评估COVID-19病人病情严重程度及预后。

Abstract:
ObjectiveTo investigate the clinical significance and correlation of the serum levels of D-dimer, C reactive protein(CRP) and interleukin-6(IL-6) in corona virus disease 2019(COVID-19).
MethodsThe clinical data of 128 COVID-19 patients were retrospectively analyzed, and the patients were divided into the ordinary group(102 cases), severe group(22 cases) and critical group(4 cases) according to the clinical classification.Ninety non-COVID-19 and non-severe community-acquired pneumonia patients were set as the control group.The differences of the serum levels of D-dimer, CRP and IL-6 between the control group and ordinary group, and among the ordinary group, severe group and critical group were compared.The correlation between the serum levels of D-dimer and CRP, IL-6 in patients with COVID-19 were analyzed.
ResultsThe serum levels of D-dimer and CRP in ordinary group were lower than those in control group(P < 0.05), and there was no statistical significance in the serum level of IL-6 between two groups(P>0.05).There were statistical significance in the serum levels of D-dimer, CRP and IL-6 among the ordinary group, severe group and critical group(P < 0.01).The serum levels of D-dimer, CRP and IL-6 in severe group and critical group were higher than those in ordinary group(P < 0.05), and the serum levels of D-dimer in COVID-19 patients were positively correlated with the serum levels of CRP and IL-6(P < 0.01).
ConclusionsThe serum levels of D-dimer, CRP and IL-6 are conducive to assess the severity and prognosis of patients with COVID-19.

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