ObjectiveTo evaluate the effects of par plana vitrectomy, inverted limiting membrane(ILM) packing and vitreous cavity disinfected air filling in the treatment of large-aperture idiopathic macular hole.

MethodsTwenty-eight eyes with large-aperture idiopathic macular hole were divided into the group A and group B (14 cases each group).Group A was treated with PPV, ILM packing and vitreous cavity disinfected air filling, and group B was treated with autogenous blood blocking macular hole based on ILM packing.All cases were followed up for 6 months, the best corrected visual acuity, slit lamp examination, ophthalmoscopy and optical coherence tomography before operation and after 1, 3 and 6 months of surgery were recorded.The difference of the curative effect between two groups was analyzed.

ResultsThe scores in group A after 1, 3, and 6 months of surgery decreased compared with those before surgery(P < 0.05 to P < 0.01).The scores in group B after 1, 3, and 6 months of surgery significantly decreased compared with those before surgery(P < 0.01), and which in group B after 6 months of surgery decreased compared with that after 1 month of surgery(P < 0.05).The hole closure rates in group A and group B were 92.6% and 100%, respectively.No high intraocular pressure or retinal detachment occurred in all patients.

ConclusionsThe postoperative visual acuity in two groups increases gradually, the hiatus closure rate after autologous blood occlusion is improved compared with that of simple inner boundary membrane filling, and the treatment of large-aperture idiopathic macular hole is safe and effective.