ObjectiveTo investigate the depression condition and related influencing factors in patients with maintenance hemodialysis(MHD).

MethodsA tolal of 219 uremic patients treated with hemodialysis were investigated, and 216 healthy people were set as the control.The depression condition was evaluated using the self-rating depression scale(SDS) made by W.K.Zuang and general condition questionnaire.The disease related laboratory indicators were detected and analyzed.

ResultsThe incidence rate of the depression in MHD patients was significantly higher than that in control group.The differences of the effects of family income, course of illness, complications and social support on the SDS score in MHD patients were statistically significant(P < 0.05 to P < 0.01).Among MHD patients, the levels of blood urea nitrogen(BUN), serum creatinine(SCr), serum phosphorus and thyroid hormone(PTH) in depression group were higher than those in non-depression group(P < 0.05 to P < 0.01).The results of Pearson correlation analysis showed that the levels of BUN, SCr, blood phosphorus and PTH in patients were positively correlated with the SDS score of depression(P < 0.05 to P < 0.01).The MHD patients with low family income, long course of disease, complications and lack of social support were more likely to develop depression(P < 0.05 to P < 0.01).The results of multiple regression analysis of the significantly relevant factors showed that the family income, social support, blood phosphorus level and thyroid hormone level were the independent influencing factors of depression in MHD patients.

ConclusionsThe related influencing factors of depression in MHD patients should be emphasized in clinic, the early intervention should be given to reduce the occurrence of depression, and improve the quality of life of patients.