ObjectiveTo investigate the occurrence of repeated wheezing after bronchiolitis in infants, and explore its related factors.

MethodsThe asthmatic attack in 102 infants with bronchiolitis were analyzed during the following-up period.The infant patients were grouped according to the wheezing.The general information, family history of asthma, pet contact history, history of allergic disease and bronchiolitis were compared between two groups.

ResultsAmong 102 children, 3 cases lost.During 3, 6, 9 and 12 months of following-up, at least one time wheeze occurred in 16 cases(16.16%), 34 cases(34.34%), 39 cases(39.39%) and 43 cases(43.43%), respectively, During 12 months of following-up one wheeze occurred in 8 cases, two wheezes occurred in 11 cases, and more than three wheezes occurred in 24 cases.The results of single factor analysis showed that the differences of the breast feeding less than 3 months, passive smoking history, eczema history, repeated lower respiratory tract infection history, family allergic disease history, severe bronchiolitis, respiratory syncytial virus infection and food allergy between repeated and non-repeated wheezing groups were statistically significant(P < 0.05 to P < 0.01).The results of logistic analysis showed that the severe bronchiolitis, eczema, family allergic disease and recurrent lower respiratory tract infection were the risk factors of repeated wheezing(P < 0.05), while breast-feeding for more than 3 months was the protective factor of repeated wheezing after bronchiolitis(P < 0.01).

ConclusionsThe severe bronchiolitis, family history of allergic diseases, eczema and repeated lower respiratory tract infection are the high risk factors of repeated wheezing after bronchiolitis.Clinical prevention and treatment should be done to reduce the incidence of wheezing.