ObjectiveTo investigate the diagnostic value of human epididymal secretory protein 4 (HE4), carbohydrate antigen 125 (CA125) combined with ultrasound in postmenopausal endometrial carcinoma.

MethodsA total of 101 patients with postmenopausal endometrial cancer were selected as malignant group, 103 patients with postmenopausal endometrial hyperplasia as benign group, and 105 menopausal healthy examinees as control group.The levels of HE4 and CA125 in three groups were detected.The sensitivity, specificity and diagnostic odds ratio were calculated under combined detection, and the area under the receiver operating characteristic curve (AUC) was calculated.

ResultsSeventy-eight abnormal cases were found in malignant group by colorful Doppler ultrasound.The expression level and positive rate of HE4 and CA125 in malignant group were higher than those in benign group and control group, and which in benign group were higher than those in control group(P < 0.05 to P < 0.01).The sensitivity and diagnostic odds ratio of combined diagnosis were higher than that of HE4, CA125 and ultrasound alone(P < 0.01 and P < 0.05), but the specificity between them was not statistically significant(P>0.05).The AUC values of simple HE4, CA125 and ultrasound diagnosis at the best diagnosis point were 0.725, 0.713 and 0.723, respectively, and the AUC value of combined diagnosis of HE4, CA125 and ultrasound was 0.867.

ConclusionsCompared with simple diagnosis, the overall diagnostic efficacy of HE4 and CA125 combined with ultrasound for endometrial tumor is better, which has better clinical application and promotion value.