李曦颖, 黄礼年. 动态监测NLR、PLR变化与晚期肺腺癌一线化疗疗效及预后关系[J]. 蚌埠医学院学报, 2020, 45(11): 1486-1490. DOI: 10.13898/j.cnki.issn.1000-2200.2020.11.009
    引用本文: 李曦颖, 黄礼年. 动态监测NLR、PLR变化与晚期肺腺癌一线化疗疗效及预后关系[J]. 蚌埠医学院学报, 2020, 45(11): 1486-1490. DOI: 10.13898/j.cnki.issn.1000-2200.2020.11.009
    LI Xi-ying, HUANG Li-nian. Relationship between dynamic monitoring NLR and PLR, and efficacy of first-line chemotherapy and prognosis of advanced lung adenocarcinoma[J]. Journal of Bengbu Medical College, 2020, 45(11): 1486-1490. DOI: 10.13898/j.cnki.issn.1000-2200.2020.11.009
    Citation: LI Xi-ying, HUANG Li-nian. Relationship between dynamic monitoring NLR and PLR, and efficacy of first-line chemotherapy and prognosis of advanced lung adenocarcinoma[J]. Journal of Bengbu Medical College, 2020, 45(11): 1486-1490. DOI: 10.13898/j.cnki.issn.1000-2200.2020.11.009

    动态监测NLR、PLR变化与晚期肺腺癌一线化疗疗效及预后关系

    Relationship between dynamic monitoring NLR and PLR, and efficacy of first-line chemotherapy and prognosis of advanced lung adenocarcinoma

    • 摘要:
      目的探讨中性粒细胞淋巴细胞比率(NLR)及血小板淋巴细胞比率(PLR)的动态变化对晚期肺腺癌病人化疗疗效及生存期的预测价值。
      方法回顾性分析193例经一线化疗的晚期肺腺癌病人病历资料,收集其化疗前、化疗2周期后及化疗4周期后的相关资料进行疗效评定,并分别计算NLR、PLR;分析NLR、PLR的动态变化与各种临床特征、一线化疗疗效及总生存期(OS)之间的关系。
      结果NLR、PLR水平在化疗前及化疗后疾病进展组均高于完全缓解+部分缓解+疾病稳定组(P < 0.01);在化疗疗效方面,除NLR4(P>0.05)外,NLR0、NLR2、PLR0、PLR2、PLR4与2周期化疗疗效呈负相关关系(P < 0.05~P < 0.01);而NLR0、NLR2、NLR4、PLR0、PLR2、PLR4与4周期化疗疗效均呈负相关关系(P < 0.01);Kaplan-Meier生存分析表明,OS在不同NLR0、NLR4、PLR0、PLR2、PLR4、2周期化疗疗效及4周期化疗疗效中差异均有统计学意义(P < 0.01),且多因素分析表明,NLR0与PLR4是生存期的独立危险因素(P < 0.05和P < 0.01)。
      结论NLR、PLR与一线化疗晚期肺腺癌疗效及生存密切相关,治疗前NLR与化疗4周后PLR是一线化疗晚期肺腺癌病人的独立预后因素。

       

      Abstract:
      ObjectiveTo investigate the predictive value of dynamic monitoring the neutrophil-to-lymphocyte ratio(NLR) and platelet-to-lymphocyte ratio(PLR) in the chemotherapeutic effects and lifetime of lung adenocarcinoma patients.
      MethodsThe clinical data of 193 advanced lung adenocarcinoma patients treated with first-line chemotherapy were retrospectively analyzed.The relevant data of patients before chemotherapy, after 2 and 4 cycles of chemotherapy were collected.The curative effects of patients were evaluated, and the NLR and PLR were calculated.The relationship between the dynamic changes of NLR and PLR, and various clinical features, first-line chemotherapy efficacy and overall survival(OS) were analyzed.
      ResultsThe levels of NLR and PLR in PD group before and after chemotherapy were higher than those in CR group, PR group and SD group(P < 0.01).In terms of the efficacy of chemotherapy, except for NLR4(P>0.05), the NLR0, NLR0, PLR0, PLR2 and PLR4 were negatively correlated with the efficacy of 2-cycle chemotherapy(P < 0.05 to P < 0.01).The NLR0, NLR2, NLR4, PLR0, PLR2 and PLR4 were negatively correlated with the efficacy of 4-cycle chemotherapy(P < 0.01).The results of Kaplan-Meier survival analysis showed that the OS was significantly correlated with the NLR0, NLR4, PLR0, PLR2, PLR4, efficacy of 2-cycle chemotherapy and efficacy of 4-cycle chemotherapy(P < 0.01).The results of multivariate analysis showed that the NLR0 and PLR4 were the independent risk factors of survival(P < 0.05 and P < 0.01).
      ConclusionsThe NLR and PLR are closely related to the efficacy and survival of first-line chemotherapy for advanced lung adenocarcinoma.The NLR before treatment and PLR after 4 cycle chemotherapy are the independent prognostic factors of advanced lung adenocarcinoma patients treated with first-line chemotherapy.

       

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