李嘉, 危松青, 王曼知, 石家云. 布地奈德联合高流量氧疗对急性呼吸窘迫综合征患儿一氧化氮、乳酸的影响[J]. 蚌埠医学院学报, 2020, 45(11): 1498-1500, 1504. DOI: 10.13898/j.cnki.issn.1000-2200.2020.11.012
    引用本文: 李嘉, 危松青, 王曼知, 石家云. 布地奈德联合高流量氧疗对急性呼吸窘迫综合征患儿一氧化氮、乳酸的影响[J]. 蚌埠医学院学报, 2020, 45(11): 1498-1500, 1504. DOI: 10.13898/j.cnki.issn.1000-2200.2020.11.012
    LI Jia, WEI Song-qing, WANG Man-zhi, SHI Jia-yun. Effect of budesonide combined with high-flow oxygen therapy on nitric oxide and lactate in children with acute respiratory distress syndrome[J]. Journal of Bengbu Medical College, 2020, 45(11): 1498-1500, 1504. DOI: 10.13898/j.cnki.issn.1000-2200.2020.11.012
    Citation: LI Jia, WEI Song-qing, WANG Man-zhi, SHI Jia-yun. Effect of budesonide combined with high-flow oxygen therapy on nitric oxide and lactate in children with acute respiratory distress syndrome[J]. Journal of Bengbu Medical College, 2020, 45(11): 1498-1500, 1504. DOI: 10.13898/j.cnki.issn.1000-2200.2020.11.012

    布地奈德联合高流量氧疗对急性呼吸窘迫综合征患儿一氧化氮、乳酸的影响

    Effect of budesonide combined with high-flow oxygen therapy on nitric oxide and lactate in children with acute respiratory distress syndrome

    • 摘要:
      目的研究布地奈德联合高流量氧疗对急性呼吸窘迫综合征患儿一氧化氮(NO)、乳酸的影响。
      方法选取急性呼吸窘迫综合征患儿90例,按照随机数字表法分为氧疗组和联合组,各45例。氧疗组给予经鼻高流量氧疗治疗,联合组在氧疗组基础上给予布地奈德治疗。比较2组患儿治疗前后动脉血氧分压(PaO2)、动脉二氧化碳分压(PaCO2)、氧合指数和NO、乳酸水平及肺功能指标。
      结果2组患儿治疗后PaCO2均较治疗前降低,PaO2、氧合指数均较治疗前升高(P < 0.05~P < 0.01),且联合组PaCO2明显低于氧疗组,PaO2、氧合指数均明显高于氧疗组(P < 0.01)。2组患儿治疗后NO、乳酸水平均较治疗前降低(P < 0.05),且联合组NO、乳酸水平均明显低于氧疗组(P < 0.01)。联合组患儿治疗后潮气量、用力呼气量、1秒用力呼气量、最大呼气流量水平均明显高于氧疗组(P < 0.01)。联合组患儿治疗有效率为93.33%(42/45),高于氧疗组的77.78%(35/45),2组患儿疗效差异有统计学意义(P < 0.01)。
      结论布地奈德联合高流量氧疗治疗儿童急性呼吸窘迫综合征效果较好,能改善患儿NO、乳酸水平,提高呼吸功能。

       

      Abstract:
      ObjectiveTo study the effects of budesonide combined with high-flow oxygen therapy on nitric oxide(NO) and lactate in children with acute respiratory distress syndrome(ARDS).
      MethodsNinety children with ARDS were randomly divided into the oxygen therapy group and combined group.The oxygen therapy group was treated with transnasal high-flow oxygen therapy, and the combined group was additionally treated with budesonide on the basis of the oxygen therapy group.The levels of PaO2, PaCO2, oxygenation index, NO and lactate, and pulmonary function before and after treatment were compared between two groups.
      ResultsAfter treatment, the level of PaCO2, and levels of PO2 and oxygenation index in two groups significantly decreased and increased compared with before treatment, respectively(P < 0.05 to P < 0.01), and the levels of PaCO2, PO2 and oxygenation index in combined group were significantly lower and higher than those in oxygen therapy group, respectively(P < 0.01).After treatment, the levels of NO and lactate in two groups decreased compared with before treatment(P < 0.05), and which in combined group were significantly lower than those in oxygen therapy group(P < 0.01).After treatment, the levels of TV, FEV, FEV1 and PEF in combined group were significantly higher than those in oxygen therapy group(P < 0.01).The effective rate in the combined group and oxygen therapy group was 93.33% and 77.78%, respectively, and the difference of which was statistically significant(P < 0.01).
      ConclusionsBudesonide combined with high-flow oxygen therapy in the treatment of children with ARDS has a good effect, which can improve the levels of NO and lactate, and respiratory function.

       

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