汪莉, 石慧芬, 江海英, 刘金霞, 陈茵. 8-isoprostane、SOD、AOA、NF-κB及iNOS在复发性流产病人中的表达研究[J]. 蚌埠医学院学报, 2020, 45(11): 1512-1514, 1517. DOI: 10.13898/j.cnki.issn.1000-2200.2020.11.016
    引用本文: 汪莉, 石慧芬, 江海英, 刘金霞, 陈茵. 8-isoprostane、SOD、AOA、NF-κB及iNOS在复发性流产病人中的表达研究[J]. 蚌埠医学院学报, 2020, 45(11): 1512-1514, 1517. DOI: 10.13898/j.cnki.issn.1000-2200.2020.11.016
    WANG Li, SHI Hui-fen, JIANG Hai-ying, LIU Jin-xia, CHEN Yin. Study on the expression levels of 8-isoprostane, SOD, AOA, NF-κB and iNOS in patients with recurrent spontaneous abortion[J]. Journal of Bengbu Medical College, 2020, 45(11): 1512-1514, 1517. DOI: 10.13898/j.cnki.issn.1000-2200.2020.11.016
    Citation: WANG Li, SHI Hui-fen, JIANG Hai-ying, LIU Jin-xia, CHEN Yin. Study on the expression levels of 8-isoprostane, SOD, AOA, NF-κB and iNOS in patients with recurrent spontaneous abortion[J]. Journal of Bengbu Medical College, 2020, 45(11): 1512-1514, 1517. DOI: 10.13898/j.cnki.issn.1000-2200.2020.11.016

    8-isoprostane、SOD、AOA、NF-κB及iNOS在复发性流产病人中的表达研究

    Study on the expression levels of 8-isoprostane, SOD, AOA, NF-κB and iNOS in patients with recurrent spontaneous abortion

    • 摘要:
      目的分析8-异构前列腺素(8-isoprostane)、超氧化物歧化酶(SOD)、血浆总抗氧化能力(AOA)、转录因子-κB(NF-κB)和诱导型一氧化氮合酶(iNOS)在复发性流产病人中的表达及影响,以探讨不明原因复发性流产发病机制。
      方法选取2018年1月至2019年10月119例产妇作为研究对象,分为不明原因复发性流产病人60例作为研究对象(病例组),进行正常妊娠分娩妇女作为参照对象59例(对照组),比较2组病人血液和绒毛蜕膜组织中的8-isoprostane、SOD、AOA等氧化应激指标及NF-κB、iNOS水平。
      结果2组病人血液中AOA水平差异无统计学意义(P>0.05),病例组病人血液中8-isoprostane、NF-κB和iNOS水平均高于对照组(P < 0.01),SOD水平明显低于对照组(P < 0.01);2组病人绒毛蜕膜组织中AOA水平差异无统计学意义(P>0.05),病例组绒毛蜕膜组织中8-isoprostane、NF-κB和iNOS水平均高于对照组(P < 0.01),SOD水平明显低于对照组(P < 0.01)。
      结论不明原因复发性流产病人血液和绒毛蜕膜组织中的8-isoprostane、SOD、NF-κB和iNOS表达与正常妊娠妇女具有明显差异,因此,其可作为预测不明原因复发性流产发生的重要因子。

       

      Abstract:
      ObjectiveTo investigate the expression levels of 8-isoprostane, SOD, AOA, NF-kB and iNOS in patients with recurrent spontaneous abortion and their effects, and explore the pathogenesis of unexplained recurrent spontaneous abortion.
      MethodsFrom January 2018 to October 2019, 119 maternal patients were selected, and divided into the case group(60 cases with unexplained recurrent abortion) and control group(59 cases with normal pregnancy delivery).The levels of 8-isoprostane, SOD, AOA and other oxidative stress indicators(NF-κB and iNOS) in the blood and villous decidua tissue were compared between two groups.
      ResultsThere was no statistical significance in the AOA level in blood between two groups(P>0.05), the levels of 8-isoprostane, NF-κB and iNOS in case group were significantly higher than those in control group(P < 0.01), and the SOD level in case group was significantly lower than that in control group(P < 0.01).The difference of the AOA level in chorion decidua tissue between two groups was not statistically significant(P>0.05), the levels of 8-isoprostane and NF-κ in chorion decidua tissue in case group were higher than those in control group(P < 0.01), and the level of SOD in case group was lower than that in control group(P < 0.01).
      ConclusionsThere are significant differences in the expression levels of 8-isoprostane, SOD, NF-κB and iNOS in blood and chorion decidua tissue between patients with unexplained recurrent abortion and normal pregnant women, and they can be used as an important factor to predict the occurrence of unexplained recurrent spontaneous abortion.

       

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