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    崔航涛, 周志强, 樊华, 徐瑞. 齐拉西酮联合低频重复经颅磁刺激对老年重症精神分裂症病人BNDF、IL-6、Hcy水平与认知功能障碍的影响[J]. 蚌埠医科大学学报, 2020, 45(11): 1521-1524. DOI: 10.13898/j.cnki.issn.1000-2200.2020.11.019
    引用本文: 崔航涛, 周志强, 樊华, 徐瑞. 齐拉西酮联合低频重复经颅磁刺激对老年重症精神分裂症病人BNDF、IL-6、Hcy水平与认知功能障碍的影响[J]. 蚌埠医科大学学报, 2020, 45(11): 1521-1524. DOI: 10.13898/j.cnki.issn.1000-2200.2020.11.019
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    CUI Hang-tao, ZHOU Zhi-qiang, FAN Hua, XU Rui. Effect of ziprasidone combined with low frequency repetitive transcranial magnetic stimulation on the levels of BNDF, IL-6 and Hcy and cognitive dysfunction in elderly patients with severe schizophrenia[J]. Journal of Bengbu Medical University, 2020, 45(11): 1521-1524. DOI: 10.13898/j.cnki.issn.1000-2200.2020.11.019
    Citation: CUI Hang-tao, ZHOU Zhi-qiang, FAN Hua, XU Rui. Effect of ziprasidone combined with low frequency repetitive transcranial magnetic stimulation on the levels of BNDF, IL-6 and Hcy and cognitive dysfunction in elderly patients with severe schizophrenia[J]. Journal of Bengbu Medical University, 2020, 45(11): 1521-1524. DOI: 10.13898/j.cnki.issn.1000-2200.2020.11.019
    shu

    齐拉西酮联合低频重复经颅磁刺激对老年重症精神分裂症病人BNDF、IL-6、Hcy水平与认知功能障碍的影响

    Effect of ziprasidone combined with low frequency repetitive transcranial magnetic stimulation on the levels of BNDF, IL-6 and Hcy and cognitive dysfunction in elderly patients with severe schizophrenia

      摘要
    • 摘要:
      目的探讨齐拉西酮联合低频重复经颅磁刺激对老年重症精神分裂症病人脑源性神经营养因子（BDNF）、白细胞介素-6（IL-6）、同型半胱氨酸（Hcy）水平与认知功能障碍的影响。
      方法选择老年重症精神分裂症病人100例，随机分为观察组和对照组，各50例。对照组采用齐拉西酮治疗；观察组采用齐拉西酮联合低频重复经颅磁刺激治疗，持续治疗2个月。比较2组病人的临床疗效、治疗前后阳性与阴性症状量表（PANSS）评分、重复性成套神经心理状态测验（RBANS）评分、Hcy水平、BDNF水平、IL-6水平及不良反应发生情况。
      结果2组治疗后PANSS评分较治疗前明显降低，RBANS评分较治疗前明显升高（P < 0.01），且观察组病人治疗后PANSS评分明显低于对照组（P < 0.01），RBANS评分明显高于对照组（P < 0.01）。2组治疗后血清BDNF水平较治疗前明显升高，IL-6、Hcy水平较治疗前明显降低（P < 0.01）；且观察组病人治疗后血清BDNF水平明显高于对照组，IL-6、Hcy水平明显低于对照组（P < 0.01）。观察组有效率（96.00%）高于对照组（84.00%）（P < 0.05），2组病人不良反应发生情况差异无统计学意义（P>0.05）。
      结论齐拉西酮联合低频重复经颅磁刺激对老年重症精神分裂症病人的疗效确切，可以改善认知功能障碍，降低IL-6、Hcy水平，提高BDNF水平，且安全性高，值得推广。

       

      Abstract:
      ObjectiveTo investigate the effects of ziprasidone combined with low frequency repetitive transcranial magnetic stimulation on the levels of BNDF, IL-6 and Hcy, and cognitive dysfunction in elderly patients with severe schizophrenia.
      MethodsOne hundred elderly patients with severe schizophrenia were randomly divided into the observation group and control group(50 cases in each group).The control group was treated with ziprasidone, and the observation group was treated with ziprasidone combined with low frequency repetitive transcranial magnetic stimulation for 2 months.The clinical efficacy, positive and negative symptom scale(PANSS) scores before and after treatment, repeatable battery for the assessment of neuropsychological status(RBANS) scores, levels of Hcy, BDNF and IL-6, and adverse reactions were compared between two groups.
      ResultsCompared with before treatment, the PANSS scores decreased, the RBANS scores increased in two groups after treatment(P < 0.01).After treatment, the scores of PANSS in observation group was lower than that in control group(P < 0.01), and the scores of RBANS in observation group was higher than that in control group(P < 0.01).Compared with before treatment, the serum level of BDNF increased, the levels of IL-6 and Hcy decreased in two groups after treatment(P < 0.01).After treatment, the serum level of BDNF in observation group was higher than that in control group, and the levels of IL-6 and Hcy in observation group was lower than that in control group(P < 0.01).The effective rate in observation group(96.00%) was higher than that in control group(84.00%) (P < 0.05).There was no statistical significance in the incidence rate of adverse reactions between two groups(P>0.05).
      ConclusionsZiprasidone combined with low frequency repetitive transcranial magnetic stimulation is effective in the treatment of elderly patients with severe schizophrenia.It can improve cognitive impairment, reduce the levels of IL-6 and Hcy, and improve the level of BDNF.It is safe and worthy of promotion.

       

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