高血压病人动态动脉硬化指数与血浆纤维蛋白原及D-二聚体的相关性研究

朱雁洲; 刘晓斌; 郑原印; 范金茂; 陈康

doi:10.13898/j.cnki.issn.1000-2200.2020.12.017

高血压病人动态动脉硬化指数与血浆纤维蛋白原及D-二聚体的相关性研究

Correlations of ambulatory arterial stiffness index with plasma fibrinogen and D-dimer in patients with hypertension

摘要

摘要:
目的探讨高血压病人动态动脉硬化指数（AASI）与血浆纤维蛋白原（FIB）及D-二聚体（D-D）的关系。
方法选取高血压病人220例，根据AASI中位数的大小分为A组（24h AASI < 0.52，n＝106）和B组（24h AASI≥0.52，n＝114）。比较各组间血FIB、D-D水平，并进行Pearson/Spearman相关分析与多元线性回归分析。
结果A组的年龄、高血压病程、收缩压、总胆固醇、低密度脂蛋白胆固醇（LDL-C）、FIB、D-D均低于B组（P < 0.05）。Pearson或Spearman相关性分析显示，高血压病人AASI与年龄（r=0.231，P < 0.05）、高血压病程（r=0.685，P < 0.05）、收缩压（r=0.721，P < 0.05）、血尿素氮（r=0.113，P < 0.05）、总胆固醇（r=0.628，P < 0.05）、LDL-C（r=0.666，P < 0.05）、FIB（r=0.887，P < 0.05）、D-D（r=0.668，P < 0.05）相关。多元线性回归分析显示，AASI与病程（β=0.107，P < 0.05）、收缩压（β=0.158，P < 0.05）、LDL-C（β=0.102，P < 0.05）、FIB（β=0.585，P < 0.05）、D-D（β=0.139，P < 0.05）相关。
结论高血压病人AASI与血浆FIB及D-D相关，临床上通过药物干预血FIB及D-D的值可能延缓或控制动脉粥样硬化的进程。

Abstract:
ObjectiveTo investigate the relationship between ambulatory arterial stiffness index(AASI)and plasma fibrinogen(FIB)and D-dimer(D-D)in patients with hypertension.
MethodsAccording to the median value of AASI, 220 patients with hypertension were divided into group A(24 h AASI < 0.52, n=106)and group B(24 h AASI≥0.52, n=114).The levels of FIB and D-D were compared between the two groups.Pearson or Spearman correlation analysis and multiple linear regression analysis were performed.
ResultsThe age, duration of hypertension, systolic blood pressure, total cholesterol, low density lipoprotein cholesterol(LDL-C), FIB and D-D in group A were lower than those in group B(P < 0.05).Pearson or Spearman correlation analysis showed that AASI in patients with hypertension was correlated with age(r=0.231, P < 0.05), duration of hypertension(r=0.685, P < 0.05), systolic blood pressure(r=0.721, P < 0.05), blood urea nitrogen(r=0.113, P < 0.05), total cholesterol(r=0.628, P < 0.05), LDL-C(r=0.666, P < 0.05), FIB(r=0.887, P < 0.05), and D-D(r=0.668, P < 0.05).Multiple linear regression analysis showed that AASI was correlated with duration of disease(β=0.107, P < 0.05), systolic blood pressure(β=0.158, P < 0.05), LDL-C(β=0.102, P < 0.05), FIB(β=0.585, P < 0.05), and D-D(β=0.139, P < 0.05).
ConclusionsAASI in patients with hypertension is correlated with plasma FIB and D-D.Intervening the level of FIB and D-D by medicine may delay or control the progress of atherosclerosis.

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