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    申金付, 王卓群, 李茂, 谢树永, 康京京. 中性粒细胞与淋巴细胞比值与2型糖尿病不同程度白蛋白尿的相关性分析[J]. 蚌埠医科大学学报, 2020, 45(12): 1677-1680. DOI: 10.13898/j.cnki.issn.1000-2200.2020.12.022
    引用本文: 申金付, 王卓群, 李茂, 谢树永, 康京京. 中性粒细胞与淋巴细胞比值与2型糖尿病不同程度白蛋白尿的相关性分析[J]. 蚌埠医科大学学报, 2020, 45(12): 1677-1680. DOI: 10.13898/j.cnki.issn.1000-2200.2020.12.022
    shu
    SHEN Jin-fu, WANG Zhuo-qun, LI Mao, XIE Shu-yong, KANG Jing-jing. Correlation analysis between the ratio of neutrophils to lymphocytes and different levels of albumin in type 2 diabetes mellitus[J]. Journal of Bengbu Medical University, 2020, 45(12): 1677-1680. DOI: 10.13898/j.cnki.issn.1000-2200.2020.12.022
    Citation: SHEN Jin-fu, WANG Zhuo-qun, LI Mao, XIE Shu-yong, KANG Jing-jing. Correlation analysis between the ratio of neutrophils to lymphocytes and different levels of albumin in type 2 diabetes mellitus[J]. Journal of Bengbu Medical University, 2020, 45(12): 1677-1680. DOI: 10.13898/j.cnki.issn.1000-2200.2020.12.022
    shu

    中性粒细胞与淋巴细胞比值与2型糖尿病不同程度白蛋白尿的相关性分析

    Correlation analysis between the ratio of neutrophils to lymphocytes and different levels of albumin in type 2 diabetes mellitus

      摘要
    • 摘要:
      目的探讨中性粒细胞与淋巴细胞比值（NLR）与2型糖尿病（T2DM）病人不同程度白蛋白尿的相关性。
      方法收集T2DM病人299例，按照白蛋白尿程度分为白蛋白尿正常组（NAU组）97例，微量白蛋白尿组（MAU组）91例及临床蛋白尿组（CAU组）111例。分析各组临床资料、NLR及实验室指标特征。
      结果MAU组病人年龄、病程、空腹血糖（FBG）、糖化血红蛋白（HbA1c）、胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）、超酶C-反应蛋白（hs-CRP）、胱抑素C（Cys-C）及NLR均高于NAU组（P < 0.05~P < 0.01），高密度脂蛋白胆固醇（HDL-C）低于NAU组（P < 0.05）；CAU组病人年龄、病程、收缩压、FBG、HbA1c、TC、TG、LDL-C、血肌酐（Cr）、尿酸（UA）、hs-CRP、Cys-C及NLR均高于NAU组（P < 0.05~P < 0.01），病程、FBG、HbA1c、Cr、UA、hs-CRP及NLR也均高于MAU组（P < 0.01），HDL-C低于NAU组（P < 0.01）。多元logisitic回归分析显示，病程、收缩压、舒张压、FBG、TG、LDL-C、Cr、hs-CRP、Cys-C及NLR是影响T2DM白蛋白尿的相关因素（P < 0.05~P < 0.01）。NLR与年龄、病程、FBG、HbA1C、TC、HDL-C、Cr、hs-CRP因素有统计学关联（P < 0.05~P < 0.01）。
      结论NLR与2型糖尿病白蛋白尿的发生相关。

       

      Abstract:
      ObjectiveTo investigate the correlation between the neutrophil-to-lymphocyte ratio(NLR)and different levels of albumin in type 2 diabetes mellitus(T2DM).
      MethodsTwo hundred ninety-nine patients with T2DM were divided into the NAU group(n=97), MAU group(n=91)and CAU group(n=111)according to the levels of albumin.The clinical data, NLR and biochemical characteristics in three groups were analyzed.
      ResultsThe age, course of disease, and levels of FBG, HbA1c, TC, TG, LDL-C, hs-CRP, Cys-C and NL in MAU group were higher than those in NAU group(P < 0.05 to P < 0.01), but the level of HDL-C in MAU group was lower than that in NAU group(P < 0.05).The age, course of disease, and levels of SBP, FBG, HbA1c, TC, TG, LDL-C, Cr, UA, hs-CRP, Cys-C and NLR in CAU group were higher than those in NAU group(P < 0.05 to P < 0.01), the course of disease, FBG, HbA1c, Cr, UA, hs-CRP and NLR in CAU group were higher than those in MAU group(P < 0.05), and the level of HDL-C in MAU group was lower than that in NAU group(P < 0.05).The results of multivariate logistic regression showed that the course of disease, and levels of SBP, DBP, FBG, TG, LDL-C, Cr, hs-CRP, Cys-C and NLR were the relevant factors of influencing the albuninuria in T2DM.The age, duration, and levels of FBG, HbA1C, TC, HDL-C, Cr and hs-CRP were correlation with NLR(P < 0.05 to P < 0.01).
      ConclusionsThe NLR is associate with the severity of albuninuria in T2DM.

       

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