黄丹丹, 徐兴欣, 江肖. 吸烟对IgA肾病临床指标及肾脏病理的影响[J]. 蚌埠医学院学报, 2021, 46(1): 33-36. DOI: 10.13898/j.cnki.issn.1000-2200.2021.01.009
    引用本文: 黄丹丹, 徐兴欣, 江肖. 吸烟对IgA肾病临床指标及肾脏病理的影响[J]. 蚌埠医学院学报, 2021, 46(1): 33-36. DOI: 10.13898/j.cnki.issn.1000-2200.2021.01.009
    HUANG Dan-dan, XU Xing-xin, JIANG Xiao. Effect of smoking on the clinical indicators and renal pathology of IgA nephropathy[J]. Journal of Bengbu Medical College, 2021, 46(1): 33-36. DOI: 10.13898/j.cnki.issn.1000-2200.2021.01.009
    Citation: HUANG Dan-dan, XU Xing-xin, JIANG Xiao. Effect of smoking on the clinical indicators and renal pathology of IgA nephropathy[J]. Journal of Bengbu Medical College, 2021, 46(1): 33-36. DOI: 10.13898/j.cnki.issn.1000-2200.2021.01.009

    吸烟对IgA肾病临床指标及肾脏病理的影响

    Effect of smoking on the clinical indicators and renal pathology of IgA nephropathy

    • 摘要:
      目的探讨吸烟对IgA肾病临床指标和肾脏病理的影响。
      方法回顾性分析149例IgA肾病病人的吸烟状态,并分析其与病人临床指标及肾脏病理损伤指标的关系。
      结果149例IgA肾病病人中吸烟者30例(吸烟组),非吸烟者119例(非吸烟组)。吸烟组病人肾小球滤过率(eGFR)明显低于非吸烟组(P < 0.01),年龄、男性比例、三酰甘油、血糖和尿β2微球蛋白、α1微球蛋白、24 h尿蛋白均高于非吸烟组(P < 0.05~P < 0.01)。吸烟组病人的肾间质纤维化积分和肾小球毛细血管壁增厚积分均高于非吸烟组(P < 0.05)。Pearson相关分析显示,吸烟量与eGFR呈负相关关系(r=-0.219,P < 0.05),与肾间质纤维化积分和肾小管萎缩积分均呈正相关关系(r=0.183、0.187,P < 0.05)。
      结论吸烟与IgA肾病病人肾功能损伤存在相关关系,吸烟损伤肾脏病理以肾小管间质慢性化病变为主。

       

      Abstract:
      ObjectiveTo investigate the effects of smoking on the clinical indicators and renal pathology of IgA nephropathy.
      MethodsThe smoking status of 149 patients with IgA nephropathy was retrospectively analyzed, and its relationship with clinical indicators and renal pathological injury were analyzed.
      ResultsAmong 149 IgA nephropathy patients, 30 cases were smokers(smoking group)and 119 cases were non-smokers(non-smoking group).The glomerular filtration rate in smoking group was significantly lower than that in non-smoking group(P < 0.01), and the age, male ratio, and levels of triglyceride, blood glucose and urine β2 microglobulin, α1 microglobulin and 24 h urinary protein in smoking group were higher than those in non-smoking group(P < 0.05 to P < 0.01).The scores of renal interstitial fibrosis and glomerular capillary wall thickening in smoking group were higher than those in non-smoking group(P < 0.05).The results of Pearson correlation analysis showed that the smoking amount was negatively correlated with eGFR(r=-0.219, P < 0.05), and positively correlated with the scores of renal interstitial fibrosis and renal tubular atrophy(r=0.183, 0.187, P < 0.05).
      ConclusionsThere is a correlation between smoking and renal function injury in IgA nephropathy patients.The chronic tubular interstitial lesion is the main feature of renal pathology caused by smoking.

       

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