高级检索
    苏文芳. GOLPH3和VEGF在宫颈癌组织中的表达及临床意义[J]. 蚌埠医科大学学报, 2021, 46(2): 169-172. DOI: 10.13898/j.cnki.issn.1000-2200.2021.02.008
    引用本文: 苏文芳. GOLPH3和VEGF在宫颈癌组织中的表达及临床意义[J]. 蚌埠医科大学学报, 2021, 46(2): 169-172. DOI: 10.13898/j.cnki.issn.1000-2200.2021.02.008
    shu
    SU Wen-fang. Expression level and clinical significance of GOLPH3 and VEGF in cervical cancer[J]. Journal of Bengbu Medical University, 2021, 46(2): 169-172. DOI: 10.13898/j.cnki.issn.1000-2200.2021.02.008
    Citation: SU Wen-fang. Expression level and clinical significance of GOLPH3 and VEGF in cervical cancer[J]. Journal of Bengbu Medical University, 2021, 46(2): 169-172. DOI: 10.13898/j.cnki.issn.1000-2200.2021.02.008
    shu

    GOLPH3和VEGF在宫颈癌组织中的表达及临床意义

    Expression level and clinical significance of GOLPH3 and VEGF in cervical cancer

      摘要
    • 摘要:
      目的通过检测宫颈癌组织中高尔基体鳞酸化蛋白3（GOLPH3）与血管内皮生长因子（VEGF）表达水平，探讨二者在宫颈癌组织中浸润、转移的相互关系。
      方法通过免疫组织化学SP法检测43例手术切除的宫颈癌组织及宫颈癌旁组织中GOLPH3和VEGF蛋白表达情况。GOLPH3与VEGF在宫颈癌组织表达的相关性用Pearson相关性分析。
      结果GOLPH3和VEGF在宫颈癌组织中的阳性表达率为72.1%、74.42%，显著高于宫颈癌旁组织的37.21%、32.56%（P < 0.01）。GOLPH3、VEGF在宫颈癌组织中的表达与病人的肿瘤大小、分化程度、手术病理分期、淋巴结转移有显著相关性（P < 0.05~P < 0.01），与病人年龄、病理类型无明显相关性（P>0.05）。免疫组织化学结果显示，在GOLPH3阳性表达组的宫颈癌组织中VEGF阳性表达率为83.87%，明显高于GOLPH3阴性表达组的33.33%（P < 0.01），宫颈癌组织中GOLPH3表达与VEGF的表达呈正相关性（r=0.494, P < 0.01）。
      结论GOLPH3过表达通过上调VEGF的表达促进宫颈癌的癌组织中血管生成，从而促进了宫颈癌的浸润和转移。

       

      Abstract:
      ObjectiveTo detect the expression levels of Golgi phosphoprotein 3(GOLPH3)and vascular endothelial growth factor(VEGF)in cervical cancer tissues, and explore their relationship in invasion and metastasis of cervical cancer.
      MethodsThe expression levels of GOLPH3 and VEGF proteins in cervical carcinoma tissues and para-cervical cancer tissues of 43 patients were detected using immunohistochemical SP method.The correlations of GOLPH3 and VEGF levels in cervical cancer tissues were analyzed using Pearson correlation analysis.
      ResultsThe positive expression rates of GOLPH3 and VEGF in cervicer cancer tissues were 72.1% and 74.42%, respectively, which were significantly higher than those in para-cervical cancer tissues(37.21% and 32.56%)(P < 0.01).The expression levels of GOLPH3 and VEGF in cervical cancer tissue were significantly correlated with the tumor size, differentiation, surgical and pathological stage, and lymph node metastasis(P < 0.05 to P < 0.01), and not significantly correlated with the age and pathological type of patients(P>0.05).The results of immunohistochemistry showed that the positive expression rate of VEGF in cervical cancer tissues with positive GOLPH3 expression group(83.87%)was significantly higher than that in negative GOLPH3 expression group(33.33%)(P < 0.01).The expression rate of GOLPH3 was positively correlated with VEGF expression in cervical cancer tissues(r=0.494, P < 0.01).
      ConclusionsThe overexpression of GOLPH3 promotes the angiogenesis in cervical cancer tissues by upregulating the expression of VEGF, which leads to the invasion and metastasis of cervical cancer.

       

      • HTML全文
      • 参考文献(12)
      • 相关文章
      • 施引文献
    • 资源附件(0)

    /

    返回文章
    返回