血清线粒体融合蛋白-2和乙醛脱氢酶2与慢性心力衰竭的相关性研究

张冰; 张维; 胡祥稳; 李茂源; 汤阳; 卢园园; 康品方; 张宁汝

doi:10.13898/j.cnki.issn.1000-2200.2021.04.003

血清线粒体融合蛋白-2和乙醛脱氢酶2与慢性心力衰竭的相关性研究

Study on the correlation between serum levels of mitochondrial fusion protein-2, acetaldehyde dehydrogenase 2 and chronic heart failure

摘要

摘要:
目的探讨线粒体融合蛋白-2（Mfn2）、乙醛脱氢酶2（ALDH2）与慢性心力衰竭（CHF）病人的相关性研究。
方法入选CHF病人180例和健康体检人（对照组）40名。其中CHF病人按NYHA心功能分级标准将病人分为Ⅱ级46例、Ⅲ级63例、Ⅳ级71例。入院后完善NT-proBNP、心脏彩超等结果，并留取血清检测Mfn2、ALDH2水平，分析Mfn2、ALDH2与CHF病人相关性。
结果与对照组比较，Mfn2、ALDH2、LVEF在CHF组中降低，NT-proBNP、LVEDD在CHF组中增高，差异均有统计学意义（P 0.01）。CHF心功能Ⅱ级、Ⅲ级、Ⅳ级病人组间比较，Mfn2、ALDH2随着心功能降低而降低，NT-proBNP、LVEDD逐级增高，差异均有统计学意义（P < 0.01）。按照左心室射血分数（LVEF）分级发现，LVEF≤40%病人组Mfn2、ALDH2低于LVEF>40%病人，NT-proBNP、LVEDD高于LVEF>40%病人，差异均有统计学意义（P < 0.05~P < 0.01）；经Pearson相关分析，CHF组中，Mfn2与LVEDD呈负相关关系（P < 0.01），与LVEF呈正相关关系（P < 0.01），ALDH2与LVEF呈正相关关系（P < 0.01）；与进一步分析Mfn2、ALDH2以及联合诊断CHF的受试者工作特征曲线下面积分别为0.803、0.831、0.891（P < 0.05）。
结论CHF病人随着心功能减退，血清中的Mfn2、ALDH2水平随着减低；Mfn2、ALDH2与CHF相关指标具有相关性，从而对临床评估病情及诊断可能有重要作用。

Abstract:
ObjectiveTo investigate the correlation between the levels of mitochondrial fusion protein-2(Mfn2), acetaldehyde dehydrogenase 2(ALDH2) and chronic heart failure(CHF).
MethodsOne hundred and eighty CHF patients and 40 healthy people(control group) were investigated.According to the NYHA heart function classification standard, the CHF patients were divided into the class Ⅱ in 46 cases, class Ⅲ in 63 cases and class Ⅳ in 71 cases.After admission, the results of NT-proBNP and cardiac color Doppler ultrasound were improved, the serum levels of Mfn2 and ALDH2 were detected, and the correlation between Mfn2, ALDH2 and CHF was analyzed.
ResultsCompared with the control group, the serum levels of Mfn2, ALDH2 and LVEF decreased, the serum levels of NT-proBNP and LVEDD increased in the CHF group, and the differences of which were statistically significant(P < 0.01).Among the class Ⅱ, Ⅲ and Ⅳ heart function groups, the serum levels of Mfn2 and ALDH2 decreased with the decreasing of heart function, the serum levels of NT-proBNP and LVEDD increased with the increasing of heart function, and the differences of which were statistically significant(P < 0.01).According to the LVEF classification, the serum levels of Mfn2 and ALDH2 in patients with LVEF ≤ 40% were lower than those in patents with LVEF>40%, and the levels of NT-proBNP and LVED in patients with LVEF ≤ 40% were higher than those in patents with LVEF>40%(P < 0.05 to P < 0.01).The results of Pearson correlation analysis showed that the level of Mfn2 was negatively correlated with LVEDD(P < 0.01), and positively correlated with LVEF(P < 0.01), while the level of ALDH2 was positively correlated with LVEF(P < 0.01).The area under ROC curve of Mfn2, ALDH2 and both combination in the diagnosis of CHF were 0.803, 0.831 and 0.891(P < 0.05).
ConclusionsWith the decreasing of cardiac function in CHF patients, the serum levels of Mfn2 and ALDH2 decrease.The Serum levels of Mfn2, ALDH2 are related to the CHF, which may play an important role in clinical assessment and diagnosis.

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