SCN4B/β4在鼻咽癌组织中的表达及意义

    Expression and significance of SCN4B/β4 in nasopharyngeal carcinoma tissue

    • 摘要:
      目的探讨电压门控钠离子通道β4亚基(SCN4B/β4)在鼻咽癌组织中的表达,并分析其临床意义。
      方法应用免疫组织化学ElivisionTM Plus法检测90例鼻咽癌病人鼻咽部活检标本和20份存档的石蜡包埋正常鼻咽黏膜组织(主要为鼻咽黏膜慢性炎)标本的SCN4B/β4表达情况,分析SCN4B/β4的阳性表达与鼻咽癌病人临床病理特征的关系。
      结果鼻咽癌病人SCN4B/β4蛋白表达率低于正常鼻咽黏膜组织病人(P < 0.01);SCN4B/β4蛋白表达在不同T分期、N分期、M分期、临床分期差异有统计学意义(P < 0.05~P < 0.01),T1~T2期、M0期、Ⅰ~Ⅱ期SCN4B/β4蛋白高表达率高于T3~T4分期、M1分期和Ⅲ~Ⅳ期,随N分期增加,SCN4B/β4蛋白高表达率下降;SCN4B/β4高表达5年生存率为85.2%,高于SCN4B/β4低表达的60.3%(P < 0.05)。
      结论鼻咽癌组织的SCN4B/β4蛋白高表达与淋巴结和远处转移呈负相关,SCN4B/β4高表达病人生存率较高。

       

      Abstract:
      ObjectiveTo explore the expression level of voltage-gated sodium channel β4 subunit(SCN4B/β4) in nasopharyngeal carcinoma tissue, and analyze its clinical significance.
      MethodsThe expression levels of SCN4B/β4 in 90 nasopharyngeal biopsy specimens from nasopharyngeal carcinoma patients and 20 archived paraffin-embedded normal nasopharyngeal mucosal tissues(mainly chronic inflammation of nasopharyngeal mucosa) were detected using the ElivisionTM Plus immunohistochemical method.The relationship between the positive expression of SCN4B/β4 and clinicopathological features in patients with nasopharyngeal carcinoma were analyzed.
      ResultsThe expression rate of SCN4B/β4 protein in nasopharyngeal carcinoma tissue was lower than that in normal nasopharyngeal mucosa(χ2=19.31, P < 0.01).The differences of the expression levels of SCN4B/β4 protein in different T stage, N stage, M stage and clinical stage were statistically significant(P < 0.05 to P < 0.01), the expression rates of SCN4B/β4 protein in stageT1-T2, M0, Ⅰ-Ⅱwere higher than that in stage T3-T4, M1 and Ⅲ-Ⅳ, and the expression rate of SCN4B/β4 protein decreased with the increasing of N stage.The survival rate of patients with high SCN4B/β4 expression was 85.2%, the survival rate of patients with low SCN4B/β4 expression was 60.3%, and the 5-year overall survival rate in patients with high expression of SCN4B/β4 was higher than that in patients with low SCN4B/β4 expression(χ2=5.35, P < 0.05).
      ConclusionsThe expression level of SCN4B/β4 protein in nasopharyngeal carcinoma is negatively correlated with the lymph node and distant metastasis.The survival rate in patients with high SCN4B/β4 expression is higher.

       

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