老年阻塞性睡眠呼吸暂停低通气综合征伴2型糖尿病病人炎症反应及睡眠质量研究

    Study on the inflammatory reaction and sleep quality in elderly patients with OSAHS complicated with type 2 diabetes mellitus

    • 摘要:
      目的探讨老年阻塞性睡眠呼吸暂停低通气综合征(OSAHS)伴2型糖尿病病人炎症反应及睡眠质量特点,为临床干预提供依据。
      方法选取经多导睡眠监测及空腹血糖检测确诊的OSAHS伴2型糖尿病病人78例,单纯OSAHS病人37例。所有病人采用酶联免疫吸附法测定血清白细胞介素-6(IL-6)、肿瘤坏死因子α(TNF-α)水平;采用疲劳严重程度量表(FSS)和Epworth嗜睡量表(ESS)评价睡眠质量。比较2组血清指标及量表评分变化。
      结果与单纯OSAHS组病人比较,老年OSAHS伴2型糖尿病组睡眠中平均每小时呼吸暂停+低通气指数(AHI)、IL-6、TNF-α、FSS和ESS得分均明显增高(P < 0.01);老年OSAHS伴2型糖尿病病人IL-6、TNF-α与AHI呈正相关关系(P < 0.05),与SpO2呈负相关(P < 0.05)。
      结论与单纯OSAHS病人比较,老年OSAHS伴2型糖尿病病人全身炎症反应更为显著,睡眠质量及睡眠紊乱更明显,血清IL-6、TNF-α水平与睡眠紊乱严重程度相关。

       

      Abstract:
      ObjectiveTo investigate the characteristics of inflammatory reaction and sleep quality in elderly patients with obstructive sleep apnea-hypopnea syndrome(OSAHS) complicated with type 2 diabetes mellitus, and provide theoretical basis for clinical intervention.
      MethodsThe serum ievels of interleukin-6(IL-6) and tumor necrosis factor-α(TNF-α) in 78 OSAHS complicated with type 2 diabetes mellitus patients diagnosed by polysomnography(PSG) combnined with fasting glucose, and 37 patients with OSAHS were detected using enzyme-linked immunosorbent assay(ELISA).The sleep quality in all cases was evaluted using fatigue severity scale(FSS) and Epworth sleepiness scale(ESS).The serum levels of indicators and scale scores were compared between two groups.
      ResultsCompared with the simple OSAHS group, the AHI, serum levels of IL-6 and TNF-α and scores of FSS and ESS in OSAHS complicated with type 2 diabetes mellitus group significantly increased(P < 0.01).The serum levels of IL-6 and TNF-α were positively correlated with AHI(P < 0.05), and negatively correlated with SpO2(P < 0.05).
      ConclusionsCompared with the simple OSAHS patients, the systemic inflammatory response and sleep disorders in elderly patients with OSAHS complicated with type 2 diabetes mellitus are more significant, and the serum levels of IL-6 and TNF-α are associated with the severity of sleep disorders.

       

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