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    高频重复经颅磁刺激对男性甲基苯丙胺依赖者执行功能的影响

    Effect of high frequency repetitive transcranial magnetic stimulation on executive function in patients with methamphetamine dependence

      摘要
    • 摘要:
      目的探讨高频重复经颅磁刺激（rTMS）对甲基苯丙胺依赖者执行功能的影响。
      方法选取40例男性甲基苯丙胺依赖者为研究对象，随机分为观察组（20例）和对照组（20例），分别进行高频rTMS和伪刺激干预。运用执行功能行为评定量表（BRIEF-A）和Stroop色词测试（SCWT）来测定2组干预前后的执行功能。
      结果干预前，2组BRIEF-A总分和各因子分以及SCWT的平均反应时和正确反应数差异均无统计学意义（P>0.05）。干预后，观察组BRIEF-A总分和各因子分以及SCWT的平均反应时均低于对照组和干预前（P＜0.05~P＜0.01），观察组SCWT的正确反应数高于对照组和干预前（P＜0.01）。对照组干预前后BRIEF-A总分和各因子分以及SCWT的平均反应时和正确反应数差异无统计学意义（P>0.05）。
      结论高频rTMS能够改善甲基苯丙胺依赖者的执行功能。

       

      Abstract:
      ObjectiveTo investigate the effects of high frequency repetitive transcranial magnetic stimulation(rTMS) on the executive function in patients with methamphetamine dependence.
      MethodsForty male patients with methamphetamine dependence were randomly divided into the observation group and control group(20 cases in each group), and intervened with high frequency rTMS and sham stimulation, respectively.The executive function in two groups before and after intervention were measured by behavior rating inventory of executive function-adult version(BRIEF-A) and stroop color word test(SCWT).
      ResultsBefore intervention, the differences of the BRIEF-A total score, each factor score, average reaction time and correct reaction of SCWT between two groups were not statistically significant(P>0.05).After intervention, the BRIEF-A total score, each factor score and average reaction time of SCWT in observation group were lower than those in control group and before intervention(P < 0.05 to P < 0.01), and the correct reaction of SCWT in observation group was higher than that in control group and before intervention(P < 0.01).The differences of the BRIEF-A total score, each factor score, average reaction time and correct reaction of SCWT in control group between before and after intervention were not statistically significant(P>0.05).
      ConclusionsThe high frequency rTMS can significantly improve the executive function in patients with methamphetamine dependence.

       

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