IL-32表达与食管鳞癌放疗后预后的关系

马志宇; 郭加友; 董振; 郭嘉漪; 程贝贝; 马建新

doi:10.13898/j.cnki.issn.1000-2200.2021.05.009

IL-32表达与食管鳞癌放疗后预后的关系

Relationship between IL-32 expression and prognosis of esophageal squamous cell carcinoma after radiotherapy

摘要

摘要:
目的探讨白细胞介素（IL）-32在食管鳞癌组织中的表达及其与放疗后预后的关系。
方法回顾性分析食管鳞癌病人95例的临床资料，采用免疫组织化学法检测病人食管鳞癌组织中IL-32表达，按照IL-32表达情况分为IL-32高表达组41例和低表达组54例，比较2组病人相关临床特征及预后情况。
结果IL-32高表达组与低表达组病人性别、年龄、肿瘤位置、是否合并化疗差异均无统计学意义（P>0.05），而2组肿瘤分化程度差异有统计学意义（P < 0.05）。Kaplan-Meier生存分析显示，2组预后差异有统计学意义（P < 0.05）。Cox多因素分析显示，合并化疗和IL-32高表达是食管鳞癌放疗病人预后的独立影响因素（P < 0.05）。
结论IL-32高表达是中期食管鳞癌放疗后预后的独立影响因素。

Abstract:
ObjectiveTo investigate the expression level of interleukin(IL)-32 in esophageal squamous cell carcinoma, and its relationship with the curative effects after radiotherapy.
MethodsThe clinical data of 95 patients with esophageal squamous cell carcinoma were retrospectively analyzed.The expression levels of IL-32 in patients with esophageal squamous cell carcinoma were detected using immunohistochemistry.According to the expression level of IL-32, the patients were divided into the high expression group(41 cases) and low expression group(54 cases).The clinical features and prognosis were compared between two groups.
ResultsThere was no statistical significance in the gender, age, tumor location and chemotherapy between two groups(P>0.05), while the difference of the tumor differentiation degree between two groups was statistically significant(P < 0.05).The results of Kaplan-Meier survival analysis showed that the difference of the prognosis between two groups was statistically significant(P < 0.05).The results of Cox multivariate analysis showed that the combined chemotherapy and high expression of IL-32 were the independent influencing factors of prognosis in patients with esophageal squamous cell carcinoma(P < 0.05).
ConclusionsThe high expression of IL-32 is an independent risk factor of prognosis in patients with intermediate esophageal squamous cell carcinoma after radiotherapy.

HTML全文

参考文献(18)

施引文献

资源附件(0)