ObjectiveTo analyze the difference of the serum levels of Nesfatin-1 in patients with different glucose tolerance, and explore the relationship between Nesfatin-1 level and occurrence, development of type 2 diabetes mellitus(T2DM).

MethodsSixty pateints with impaired fasting glucose(IFG) and impaired glucose tolerance(IGT), 60 patients with T2DM and 52 health examinees at the same time were divided into the prediabetes group(PreDM), T2DM group and healthy control group, respectively.The body mass index(BMI), waist hip ratio(WHR), fasting plasma glucose(FPG), fasting insulin(FIns), glycosylated hemoglobin(HbA1c), islet β-cell function index(HOMA-β) and Nesfatin-1 were detected in three groups.

ResultsCompared with the healthy control group, the BMI, FPG, FIns, Nesfatin-1 and HbA1c increased significantly, the HOMA-β decreased significantly in PreDM group, and the differences of which were statistically significant between two groups(P < 0.01).Compared with the healthy control group, the BMI, FPG, FIns and HbA1c increased significantly, and the HOMA-β and the Nesfatin-1 decreased significantly in T2DM group, and the differences of which were statistically significant between two groups(P < 0.01).Compared with the PreDM group, the BMI, FPG and HbA1c increased significantly, the HOMA-β, Nesfatin-1 and FIns decreased significantly in T2DM group, and the differences of which were statistically significant between two groups(P < 0.01).The Nesfatin-1 was positively correlated with the WHR, BMI, FIns and HOMA-β, and negatively correlated with the FPG(P < 0.05 to P < 0.01).The results of multiple linear regression analysis showed that the FPG increased with the increasing of BMI, WHR and FIns, and decreased with the increasing of Nesfatin-1(P < 0.05 to P < 0.01).

ConclusionsThe serum Nesfatin-1 is one of the factors affecting glucose metabolism.The decrease of Nesfatin-1 level is likely to be involved in the occurrence and development of T2DM.