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    多参数3.0T MRI在HER-2阳性乳腺癌中的应用

    Application value of multi-parameter 3.0T-MRI in HER-2 positive breast cancer

      摘要
    • 摘要:
      目的探讨多参数3.0T-MRI对人表皮生长因子受体2(HER-2)阳性乳腺癌诊断的临床应用价值。
      方法回顾性分析74例经病理证实的乳腺癌病人影像学特征及临床资料，所有病人术前均行乳腺MRI检查。根据术后病理免疫组织化学HER-2表达情况分为2组，其中HER-2阳性组34例，HER-2阴性组40例。比较2组在病人年龄、病灶长径、形态、边缘、强化方式、ADC值及病灶时间-信号强度曲线(TIC)之间的差异性，并分析HER-2阳性乳腺癌MRI影像特征。
      结果HER-2阳性组年龄(49.59±9.30)岁与阴性组年龄(45.68±9.01)岁差异无统计学意义(P>0.05)。HER-2阳性组病灶表观弥散系数值(1.01±0.23)×10-3 mm2/s高于阴性组的(0.90±0.16)×10-3 mm2/s(P < 0.05)，ROC曲线下面积(AUC)为0.663(95%CI：0.538~0.789)。HER-2阳性组病灶呈环形强化方式较阴性组多(P < 0.01)，AUC为0.689(95%CI：0.567~0.811)。2组病例在病灶长径、形态、边缘、TIC曲线的MRI特征参数方面差异均无统计学意义(P>0.05)。
      结论HER-2阳性乳腺癌MRI影像表现具有一定的特征性，为病人术前评估、临床治疗方案制定、预后判断提供重要参考。

       

      Abstract:
      ObjectiveTo explore the clinical value of multi-parameter 3.0T-MRI in the diagnosis of human epidermal growth factor receptor 2(HER-2)positive breast cancer.
      MethodsThe imaging features and clinical data of 74 patients with breast cancer confirmed by pathology were retrospectively analyzed.The breast MRI in all patients were detected before operation.According to the expression of HER-2 detected by postoperative pathological immunohistochemistry, the patients were divided into the HER-2 positive group(34 cases) and HER-2 negative group(40 cases).The differences of the age, length, diameter, shape and edge of lesions, enhancement mode, apparent diffusion coefficient(ADC) value and time-intensity curve(TIC) curve were compared between two groups, and the MRI features of the HER-2 positive breast cancer were analyzed.
      ResultsThe difference of the age between the HER-2 positive group(49.59±9.30) years old and HER-2 negative group(45.68±9.01) years old was not statistically significant(P>0.05).The ADC value of lesions in HER-2 positive group(1.01±0.23)×10-3mm2/s was higher than that in HER-2 negative group(0.90±0.16)×10-3mm2/s(P < 0.05), and the area under ROC curve(AUC) was 0.663(95%CI: 0.538-0.789).The ring enhancement patterns of lesions in HER-2 positive group was more than that in HER-2 negative group(P < 0.01), and AUC was 0.689(95%CI: 0.567-0.811).The differences of the length, diameter, shape and edge of lesions, and MRI characteristic parameters of TIC curve were not statistically significant between two groups(P>0.05).
      ConclusionsThe MRI findings of the HER-2 positive breast cancer have certain characteristics, which can provide an important reference for the preoperative evaluation, clinical treatment and prognosis of patients.

       

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