李靖, 谢波, 汪虎, 马家驰, 张晨嵩, 潘成武, 王庆康, 贾建光. 胃癌病人全胃切除术后早期经口营养与空肠营养管肠内营养的对比研究[J]. 蚌埠医学院学报, 2021, 46(8): 1007-1010. DOI: 10.13898/j.cnki.issn.1000-2200.2021.08.005
    引用本文: 李靖, 谢波, 汪虎, 马家驰, 张晨嵩, 潘成武, 王庆康, 贾建光. 胃癌病人全胃切除术后早期经口营养与空肠营养管肠内营养的对比研究[J]. 蚌埠医学院学报, 2021, 46(8): 1007-1010. DOI: 10.13898/j.cnki.issn.1000-2200.2021.08.005
    LI Jing, XIE Bo, WANG Hu, MA Jia-chi, ZHANG Chen-song, PAN Cheng-wu, WANG Qing-kang, JIA Jian-guang. Comparative study of the early oral nutrition and enteral nutrition via jejunal feeding tube in patients with gastric cancer after total gastrectomy[J]. Journal of Bengbu Medical College, 2021, 46(8): 1007-1010. DOI: 10.13898/j.cnki.issn.1000-2200.2021.08.005
    Citation: LI Jing, XIE Bo, WANG Hu, MA Jia-chi, ZHANG Chen-song, PAN Cheng-wu, WANG Qing-kang, JIA Jian-guang. Comparative study of the early oral nutrition and enteral nutrition via jejunal feeding tube in patients with gastric cancer after total gastrectomy[J]. Journal of Bengbu Medical College, 2021, 46(8): 1007-1010. DOI: 10.13898/j.cnki.issn.1000-2200.2021.08.005

    胃癌病人全胃切除术后早期经口营养与空肠营养管肠内营养的对比研究

    Comparative study of the early oral nutrition and enteral nutrition via jejunal feeding tube in patients with gastric cancer after total gastrectomy

    • 摘要:
      目的探讨胃癌病人全胃切除术后早期经口肠内营养的安全性与可行性。
      方法选择行腹腔镜辅助根治性全胃切除术的胃癌病人,依照肠内营养方式不同分为早期经口营养(无营养管组,25例)和经空肠营养管肠内营养(有营养管组,23例)。分析比较2组病人术后并发症发生情况、术后应激反应指标、术后营养指标、术后肠道屏障功能指标、术后排气时间及术后住院时间。
      结果2组病人在术后营养指标、术后排气时间及住院时间方面差异均无统计学意义,在术后咽喉疼痛、腹泻发生率方面,无营养管组明显优于有营养管组(P < 0.01和P < 0.05),且术后C反应蛋白水平、血D-乳酸和I-FABP水平,无营养管组均低于有营养管组(P < 0.05~P < 0.01)。
      结论对于全胃切除的胃癌病人,与经鼻空肠营养管肠内营养相比,早期经口营养是安全的,并能减少病人咽部不适、腹泻的发生率,减轻机体应激反应,促进机体肠道屏障功能修复。

       

      Abstract:
      ObjectiveTo investigate the safety and feasibility of early oral nutrition in patients with gastric cancer after total gastrectomy.
      MethodsThe gastric cancer patients treated with laparoscope-assisted radical gastrectomy were divided into the early oral nutrition group(no nutrition tube group, 25 cases) and enteral nutrition via jejunal feeding tube group(nutrition tube group, 23 cases) according to different enteral nutrition modes.The incidence rate of postoperative complications, postoperative stress response indexes, postoperative nutrition indexes, postoperative intestinal barrier function indexes, postoperative exhaust time and postoperative hospital stay were analyzed and compared between two groups.
      ResultsThere was no statistical significance in postoperative nutrition index, postoperative exhaust time and hospital stay between two groups(P>0.05).The incidence rates of postoperative throat pain and diarrhea in no nutrition group group were significantly better than those in nutrition tube group(P < 0.01 and P < 0.05), meanwhile the levels of C-reactive protein, D-lactic acid and I-FABP in feeding group were lower than those in nutrition tube group(P < 0.05 to P < 0.01).
      ConclusionsFor gastric cancer patients treated with total gastrectomy, compared with enteral nutrition via nasal jejunal feeding tube, the early oral nutrition is safe, and can reduce the incidence rates of pharyngeal discomfort and diarrhea, reduce the stress response of the body, and promote the recovery of intestinal barrier function.

       

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