Objective To explore the correlation between thyroid hormones and metabolic indexes in type 2 diabetes mellitus patients with normal thyroid function.

Methods Three hundred type 2 diabetes patients with normal thyroid function were divided into the normal body weight group, overweight group and obesity group according to the body mass index(BMI).The levels of TSH, FT3, FT4, HbA1c, TG, TC, LDL-C, HDL-C, SCR, UA and BMI in three groups were investigated, and the correlation between thyroid hormone and metabolic syndrome indicators were analyzed.

Results The levels of TSH, TG, LDL-C, SCR, UA, SBP and DBP in normal weight group, overweight group and obesity group increased gradually in turn(P < 0.05 to P < 0.01), while the levels of HDL-C, FT3 and FT4 in three groups decreased gradually in turn(P < 0.05 to P < 0.01), , and the differences of the levels of HbA1c and TC among three groups were not statistically significant(P>0.05).The results of correlation analysis showed that the level of TSH was positively correlated with the BMI, LDL-C, TG, TC, Scr and UA(P < 0.01), negatively correlated with HDL-C(P < 0.01), and not significantly correlated with SBP, DBP and HbA1c(P>0.05);the level of FT3 was positively correlated with SBP, DBP, Scr, UA and BMI(P < 0.01), and not significant correlated with LDL-C, HDL-C, TG, TC and HbA1c(P>0.05);the level of FT4 was positively correlated with Scr and UA(P < 0.01), negatively correlated with TC(P < 0.01), and not significantly correlated with BMI, LDL-C, TG, LDL-C, HDL-C, SBP, DBP and HbA1c(P>0.05).The results of multiple regression analysis showed that the BMI, TG and UA were significantly correlated with TSH levels(P < 0.01), and not significantly correlated with hypertension(P>0.05).

ConclusionsThe changes of thyroid hormone levels and metabolic index in type 2 diabetes mellitus patients with normal thyroid function should be closely paid attention to.