高胆红素血症新生儿215例抗体检测情况分析

刘磊; 张杏杏; 夏帮坤; 姚倩; 李玉云

doi:10.13898/j.cnki.issn.1000-2200.2021.08.028

高胆红素血症新生儿215例抗体检测情况分析

Analysis of the antibody detection in 215 neonates with hyperbilirubinemia

摘要

摘要:
目的对高胆红素血症（NHB）新生儿溶血三项试验抗体检测情况进行分析，探究早期检测的临床意义。
方法对出生3 d内被确诊为NHB的新生儿215例采集静脉血进行血型检测、直抗试验、游离试验和释放试验，并对检测结果进行分析。
结果215例NHB患儿中，共有97例确诊为新生儿溶血病（HDN），其中HDN组A、B、O型占比分别为52.58%（51/97）、45.36%（44/97）和2.20%（2/97），且HDN组和非HDN组A型、B型与O型构成比差异有统计学意义（χ²=61.49，P＜0.01）。三项试验中，释放试验阳性率100%（97/97），游离试验阳性率78.35%（76/97），直抗试验阳性率16.50%（16/97），3种方法检出率差异有统计学意义（χ²=160.04，P＜0.01），释放试验>游离试验>直抗试验。
结论通过HDN微柱凝胶卡快速检测，能及时确诊，从而选取适当方法积极对症治疗。

Abstract:
ObjectiveTo analyze the antibody detection results of three hemolysis tests in 215 neonates with hyperbilirubinemia(NHB), and explore the clinical significance of early detection.
MethodsThe venous blood in 215 neonates diagnosed with NHB within 3 days after birth were collected, the blood group test, direct resistance test, free test and release test were performed, and the results were analyzed.
ResultsAmong 215 children with NHB, 97 cases were diagnosed with hemolytic disease of the newborn(HDN).The percentages of type A, type B and type O in the HDN group were 52.58%(51/97), 45.36%(44/97) and 2.20%(2/97), respectively, and the differences of composition ratio of type A, type B and type O between HDN group and non-HDN group were statistically significant(χ²=61.49, P < 0.01).The positive rates of the release test, free test and direct resistance test were 100%(97/97), 78.35%(76/97) and 16.50%(16/97), respectively.The differences of the detection rates among three methods were statistically significant(χ²=160.04, P < 0.01), and which in release test, free test and direct resistance test gradually decreased in turn.
ConclusionsThrough rapid detection of HDN microcolumn gel card, the timely diagnosis can be made, so as to select appropriate methods for positive symptomatic treatment.

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