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    彭福, 骆鹏飞, 李雷. 乳腺癌病人术前炎性指标与临床病理特征的相关性分析[J]. 蚌埠医科大学学报, 2021, 46(9): 1208-1211, 1215. DOI: 10.13898/j.cnki.issn.1000-2200.2021.09.014
    引用本文: 彭福, 骆鹏飞, 李雷. 乳腺癌病人术前炎性指标与临床病理特征的相关性分析[J]. 蚌埠医科大学学报, 2021, 46(9): 1208-1211, 1215. DOI: 10.13898/j.cnki.issn.1000-2200.2021.09.014
    shu
    PENG Fu, LUO Peng-fei, LI Lei. Correlation analysis of preoperative inflammatory indicators and clinicopathological features in breast cancer patients[J]. Journal of Bengbu Medical University, 2021, 46(9): 1208-1211, 1215. DOI: 10.13898/j.cnki.issn.1000-2200.2021.09.014
    Citation: PENG Fu, LUO Peng-fei, LI Lei. Correlation analysis of preoperative inflammatory indicators and clinicopathological features in breast cancer patients[J]. Journal of Bengbu Medical University, 2021, 46(9): 1208-1211, 1215. DOI: 10.13898/j.cnki.issn.1000-2200.2021.09.014
    shu

    乳腺癌病人术前炎性指标与临床病理特征的相关性分析

    Correlation analysis of preoperative inflammatory indicators and clinicopathological features in breast cancer patients

      摘要
    • 摘要:
      目的分析乳腺癌病人术前炎性指标与临床病理特征的关系。
      方法收集接受乳腺切除手术治疗的乳腺癌病人49例作为观察组，另选取同期行乳腺象限切除术的乳腺良性增生性疾病病人48例作为对照组。比较2组红细胞分布宽度（RDW）、中性粒细胞与淋巴细胞的比值（NLR）、血小板与淋巴细胞的比值（PLR）以及全身免疫炎症指数（SII），采用受试者工作特征（ROC）曲线分析RDW、NLR、PLR、SII对乳腺癌的诊断价值，并分析其与临床病理特征的关系。
      结果观察组RDW、NLR、PLR、SII水平均高于对照组（P < 0.05~P < 0.01）。RDW、NLR、SII的AUC高于PLR（P < 0.05），RDW与NLR、SII的ROC曲线下面积（AUC）比较，差异无统计学意义（P>0.05），NLR、PLR与SII的AUC比较，差异无统计学意义（P>0.05）。根据最佳临界值，当RDW高于12.89%时，其敏感度为79.6%，特异度为91.7%；当NLR高于1.78时，其敏感度为69.4%，特异度为89.6%；当PLR高于143.57时，其敏感度为34.7%，特异度为97.9%；当SII高于392.42时，其敏感度为65.3%，特异度为91.7%。NLR、PLR与腋窝淋巴结转移有关（P < 0.05和P < 0.01），PLR与乳腺癌临床分期有关（P < 0.05）。
      结论RDW、NLR、PLR、SII在乳腺癌病人中呈高水平，对乳腺癌有一定辅助诊断价值，且NLR腋窝淋巴结转移有关，PLR与腋窝淋巴结转移及乳腺癌临床分期有关。

       

      Abstract:
      ObjectiveTo analyze the relationship between preoperative inflammatory indicators and clinicopathological features in patients with breast cancer.
      MethodsA total of 49 breast cancer patients treated with mastectomy and 48 benign proliferative breast disease patients treated with quadrant resection were divided into the observation group and control group, respectively.The red blood cell distribution width(RDW), neutrophil to lymphocyte ratio(NLR), platelet to lymphocyte ratio(PLR) and systemic immune inflammation index(SII) were compared between two groups.The diagnostic value of RDW, NLR, PLR and SII in breast cancer were analyzed using receiver operating characteristic(ROC) curve, and the relationship between RDW, NLR, PLR and SII, and clinicopathologic features were analyzed.
      ResultsThe levels of RDW, NLR, PLR and SII in observation group were higher than those in control group(P < 0.05 to P < 0.01).The results of ROC curve analysis showed that the AUC of RDW, NL and SII were higher than that of PLR(P < 0.05), and the differences of the AUC between RDW and NLR, SII were not statistically significant(P>0.05).According to the optimal cut-off value, when the RDW was higher than 12.89%, the sensitivity and specificity of which were 79.6% and 91.7%, respectively.When the NLR was higher than 1.78, the sensitivity and specificity of which were 69.4% and 9.6%, respectively.When the PLR was higher than 143.57, the sensitivity and specificity of which were 34.7% and 97.9%, respectively.When the SII was higher than 392.42, the sensitivity and specificity of which were 65.3% and 91.7%, respectively.The NLR and PLR were correlated with the axillary lymph node metastasis(P < 0.05 and P < 0.01), and the PLR was correlated with the clinical stage of breast cancer(P < 0.05).
      ConclusionsThe levels of RDW, NLR, PLR and SII in breast cancer patients are high, which has some auxiliary diagnostic value for breast cancer.The NLR is associated with axillary lymph node metastasis, and the PLR is associated with axillary lymph node metastasis and clinical stage of breast cancer.

       

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