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    李玥, 胡祥鹏, 章礼久. 高脂血症性急性胰腺炎的临床特征分析及三酰甘油对其病情严重程度的影响[J]. 蚌埠医科大学学报, 2021, 46(9): 1212-1215. DOI: 10.13898/j.cnki.issn.1000-2200.2021.09.015
    引用本文: 李玥, 胡祥鹏, 章礼久. 高脂血症性急性胰腺炎的临床特征分析及三酰甘油对其病情严重程度的影响[J]. 蚌埠医科大学学报, 2021, 46(9): 1212-1215. DOI: 10.13898/j.cnki.issn.1000-2200.2021.09.015
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    LI Yue, HU Xiang-peng, ZHANG Li-jiu. Study on the clinical characteristics of hyperlipidemic acute pancreatitis and effects of triglyceride on the severity of disease[J]. Journal of Bengbu Medical University, 2021, 46(9): 1212-1215. DOI: 10.13898/j.cnki.issn.1000-2200.2021.09.015
    Citation: LI Yue, HU Xiang-peng, ZHANG Li-jiu. Study on the clinical characteristics of hyperlipidemic acute pancreatitis and effects of triglyceride on the severity of disease[J]. Journal of Bengbu Medical University, 2021, 46(9): 1212-1215. DOI: 10.13898/j.cnki.issn.1000-2200.2021.09.015
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    高脂血症性急性胰腺炎的临床特征分析及三酰甘油对其病情严重程度的影响

    Study on the clinical characteristics of hyperlipidemic acute pancreatitis and effects of triglyceride on the severity of disease

      摘要
    • 摘要:
      目的探讨高脂血症性急性胰腺炎（HLAP）的临床特征及三酰甘油（TG）对其病情严重程度的影响。
      方法回顾性分析68例HLAP病人及50例胆源性急性胰腺炎（BAP）的临床资料及实验室检查结果，并根据TG水平分为TG增高组（TG < 22.4 mmol/L）和TG极重度增高组（TG ≥ 22.4 mmol/L），比较2组合并疾病和病情严重程度。
      结果HLAP组的男性、合并肥胖、糖尿病、脂肪肝、复发的比例高于BAP组（P < 0.05~P < 0.01），年龄小于BAP组（P < 0.05）；SAP所占比例及住院时间2组间比较差异无统计学意义（P>0.05）。HLAP组的TG、血糖、总胆固醇和尿酸高于BAP组，血钙、丙氨酸氨基转移酶、天门冬氨酸氨基转移酶、总胆红素和直接胆红素低于BAP组，差异具有统计学意义（P < 0.05~P < 0.01）；TG增高组和TG极重度增高组发病年龄、合并肥胖、糖尿病、脂肪肝、高血压及复发的比例差异无统计学意义（P>0.05）。血清TG水平与HLAP病人的病情严重程度差异无统计学意义（P>0.05）。
      结论HLAP的发病以中年男性多见，易合并肥胖、糖尿病、脂肪肝，且易复发；更易合并血钙降低。血清TG水平显著升高，与其病情严重程度无明显相关性。

       

      Abstract:
      ObjectiveTo investigate the clinical features of hyperlipidemic acute pancreatitis(HLAP), and effects of triglyceride on the severity of disease.
      MethodsThe clinical data of 68 patients with HLAP and 50 patients with biliary acute pancreatitis(BAP) were retrospectively analyzed.According to the TG level, the HLAP patients were divided into the TG increasing group(TG < 22.4 mmol/L) and severe TG increasing group(TG ≥ 22.4 mmol/L), and the combined disease and severity of disease were compared between two groups.
      ResultsThe ratios of male, complicated with obesity, diabetes, fatty liver and relapse in HLAP group were significantly higher than those in BAP group(P < 0.05 to P < 0.01), and the age in HLAP group was lower than the BAP group(P < 0.05).There was no statistical significance in the proportion of SAP and length of hospital stay between two groups(P>0.05).The levels of TG, blood glucose(Glu), total cholesterol(TC) and uric acid(UA) in HLAP group were significantly higher than those in BAP group(P < 0.05), and the levels of blood calcium(Ca), alanine aminotransferase(ALT), aspartate aminotransferase(AST), total bilirubin(TBIL) and direct bilirubin(DBIL) in HLAP group were lower than those in BAP group(P < 0.05 to P < 0.01).There was no statistical significance in the ratios of age, combined obesity, diabetes, fatty liver, hypertension and recurrence between the TG increasing group and TG severe increasing group(P>0.05).There was no statistical significance in the TG level and severity of HLAP patients between two groups(P>0.05).
      ConclusionsThe incidence of HLAP is more common in middle-aged men, which is easy to be combined with obesity, diabetes, fatty liver, relapse and serum calcium level decreasing.The serum level of TG significantly increases, and there was no significant correlation with the severity of disease in HLAP patients.

       

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