张长洲. 胃癌根治术病人围手术期并发症及其预后的影响[J]. 蚌埠医学院学报, 2021, 46(9): 1216-1219. DOI: 10.13898/j.cnki.issn.1000-2200.2021.09.016
    引用本文: 张长洲. 胃癌根治术病人围手术期并发症及其预后的影响[J]. 蚌埠医学院学报, 2021, 46(9): 1216-1219. DOI: 10.13898/j.cnki.issn.1000-2200.2021.09.016
    ZHANG Chang-zhou. Influence of perioperative complications and prognosis in gastric cancer patients treated with radical gastrectomy[J]. Journal of Bengbu Medical College, 2021, 46(9): 1216-1219. DOI: 10.13898/j.cnki.issn.1000-2200.2021.09.016
    Citation: ZHANG Chang-zhou. Influence of perioperative complications and prognosis in gastric cancer patients treated with radical gastrectomy[J]. Journal of Bengbu Medical College, 2021, 46(9): 1216-1219. DOI: 10.13898/j.cnki.issn.1000-2200.2021.09.016

    胃癌根治术病人围手术期并发症及其预后的影响

    Influence of perioperative complications and prognosis in gastric cancer patients treated with radical gastrectomy

    • 摘要:
      目的探讨胃癌根治术病人围手术期并发症发生危险因素及其对远期预后的影响。
      方法选择106例行胃癌根治术的病人临床资料进行分析,根据病人围手术期并发症发生与否分为2组,其中有围手术期并发症的病人27例;无围手术期并发症病人79例,多因素logistic回归分析影响病人并发症发生的独立危险因素,Cox回归分析围手术期并发症对病人远期预后的影响。
      结果胃癌根治术病人围手术期并发症发生率为25.47%(27/106),2组病人一般资料(性别、吸烟及饮酒)差异均无统计学意义(P>0.05)。多因素logistic回归分析显示,年龄≥ 65岁、TNM分期较大、联合脏器切除(P < 0.01)是胃癌根治术病人发生围手术期并发症的独立危险因素。共随访病人98例(92.45%),随访时间为22~86个月,5年生存率为39.80%。存在围手术期并发症及无围手术期并发症病人的5年生存率分别为32.00%及60.37%,差异具有统计学意义(P < 0.05)。多因素Cox回归分析结果显示肿瘤大小、TNM分期、联合脏器切除及存在围手术期并发症为影响胃癌根治术病人预后的独立因素(P < 0.05~P < 0.01)。
      结论年龄、TNM分期及联合脏器切除的胃癌病人围手术期并发症的发生风险较高。临床上应采取一定的措施来降低围手术期并发症的发生,从而提高病人术后的生活质量及生存率。

       

      Abstract:
      ObjectiveTo analyze the risk factors of perioperative complications in patients treated with radical gastrectomy and their effects on long-term prognosis.
      MethodsThe clinical data of 106 patients treated with radical gastrectomy were analyzed, and the patients were divided into the perioperative complication group(27 cases) and no perioperative complication group(79 cases) according to the occurrence of perioperative complications The independent risk factors affecting the occurrence of complications were analyzed using multivariate logistic regression analysis, and the influence of perioperative complications on the long-term prognosis of patients were analyzed using Cox regression analysis.
      ResultsThe incidence rate of perioperative complications in patients treated with gastric cancer radical was 25.47%(27/106), and there was no statistical significance in general information(gender, smoking and drinking) between two groups.The results of multivariate logistic regression analysis showed that the age ≥ 65, TNM staging and combined visceral resection(P < 0.01) were the independent risk factors of perioperative complications in patients treated with radical gastrectomy.A total of 98 patients(92.45%) were followed up for 22-86 months, and the 5-year survival rate was 39.80%.The 5-year survival rates of patients with and without perioperative complications were 60.37% and 32.00%, respectively, and the difference of which was statistically significant(P < 0.05).The results of multivariate Cox regression analysis showed that the tumor size, TNM staging, combined visceral resection and perioperative complications were the independent factors affecting the prognosis of patients treated with radical gastrectomy for gastric cancer(P < 0.05 to P < 0.01).
      ConclusionsThe age, TNM staging and combined visceral resection are high risk factors of perioperative complications in patients with gastric cancer.The clinical measures should be taken to reduce the incidence of perioperative complications, so as to improve the postoperative quality of life and survival rate of patients.

       

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