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    金齐力, 韩玮玮, 程霞, 杨玉萍. 幽门螺杆菌感染对2型糖尿病病人代谢水平的影响[J]. 蚌埠医科大学学报, 2021, 46(9): 1252-1254. DOI: 10.13898/j.cnki.issn.1000-2200.2021.09.026
    引用本文: 金齐力, 韩玮玮, 程霞, 杨玉萍. 幽门螺杆菌感染对2型糖尿病病人代谢水平的影响[J]. 蚌埠医科大学学报, 2021, 46(9): 1252-1254. DOI: 10.13898/j.cnki.issn.1000-2200.2021.09.026
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    JIN Qi-li, HAN Wei-wei, CHENG Xia, YANG Yu-ping. Effect of Helicobacter pylori infection on metabolic levels in patients with type 2 diabetes mellitus[J]. Journal of Bengbu Medical University, 2021, 46(9): 1252-1254. DOI: 10.13898/j.cnki.issn.1000-2200.2021.09.026
    Citation: JIN Qi-li, HAN Wei-wei, CHENG Xia, YANG Yu-ping. Effect of Helicobacter pylori infection on metabolic levels in patients with type 2 diabetes mellitus[J]. Journal of Bengbu Medical University, 2021, 46(9): 1252-1254. DOI: 10.13898/j.cnki.issn.1000-2200.2021.09.026
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    幽门螺杆菌感染对2型糖尿病病人代谢水平的影响

    Effect of Helicobacter pylori infection on metabolic levels in patients with type 2 diabetes mellitus

      摘要
    • 摘要:
      目的探讨幽门螺杆菌（Helicobacter pylori，HP）感染对2型糖尿病（T2DM）病人代谢水平的影响。
      方法共纳入175例T2DM病人，按HP感染情况分为HP感染组和HP未感染组。收集或检测每位病人的年龄、性别、血清总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、脂蛋白-a（LP-a）、空腹血糖（Glu）、糖化血红蛋白（HbA1c）等。通过比较2组间的检测结果分析HP感染对T2DM病人代谢水平的影响。
      结果175例T2DM病人中，HP感染91例（52%），HP未感染84例（48%），T2DM合并HP感染组血清LP-a和HbA1c（%）水平均高于HP未感染组（P < 0.01）；T2DM病人HbA1c（%）>8的比例，HP感染者高于HP未感染者，差异有统计学意义（P < 0.01）；2组间其他指标差异均无统计学意义（P>0.05）。
      结论HP感染影响T2DM病人的血糖血脂代谢，可能参与代谢异常相关性疾病的发生和发展。

       

      Abstract:
      ObjectiveTo investigate the effect of Helicobacter pylori(HP) infection on metabolic levels in patients with type 2 diabetes mellitus (T2DM).
      MethodsA total of 175 patients with T2DM were included in this study.These patients were divided into two groups as HP infection-positive or -negative.For each patient, the following data were collected or measured: age, gender and laboratory parameters including total cholesterol (TC), triglyceride(TG), high-density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), lipoprotein-a (LP-a), fasting blood glucose (Glu) and glycosylated hemoglobin (HbA1c).The influence of HP infection on the metabolic levels of T2DM patients was analyzed by comparing the results between the two groups.
      ResultsAmong 175 T2DM patients, 91 patients (52%) were HP positive and 84 patients (48%) were HP infection-negative.T2DM patients infected by HP showed significantly increased Lp-a and higher HbA1c than non-infected patients (P < 0.01).Additionally, 65.9% of the patients with HbA1c >8% were found to be HP positive, 55.6% of the patients with HbA1c ≤ 8% were HP positive.The levels of other parameters were not significantly different between two groups (P>0.05).
      ConclusionsHP infection affects blood glucose and lipid metabolism in patients with T2DM, which may be involved in the occurrence and development of metabolic disorder associated diseases.

       

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