丁晓琳, 张伦军, 高洁, 张强. 血清脂肪酶、淀粉酶及C反应蛋白联合检测对急性胰腺炎诊断的意义[J]. 蚌埠医学院学报, 2021, 46(9): 1255-1257. DOI: 10.13898/j.cnki.issn.1000-2200.2021.09.027
    引用本文: 丁晓琳, 张伦军, 高洁, 张强. 血清脂肪酶、淀粉酶及C反应蛋白联合检测对急性胰腺炎诊断的意义[J]. 蚌埠医学院学报, 2021, 46(9): 1255-1257. DOI: 10.13898/j.cnki.issn.1000-2200.2021.09.027
    DING Xiao-lin, ZHANG Lun-jun, GAO Jie, ZHANG Qiang. Significance of combined determination of serum lipase, amylase and C-reactive protein in the diagnosis of acute pancreatitis[J]. Journal of Bengbu Medical College, 2021, 46(9): 1255-1257. DOI: 10.13898/j.cnki.issn.1000-2200.2021.09.027
    Citation: DING Xiao-lin, ZHANG Lun-jun, GAO Jie, ZHANG Qiang. Significance of combined determination of serum lipase, amylase and C-reactive protein in the diagnosis of acute pancreatitis[J]. Journal of Bengbu Medical College, 2021, 46(9): 1255-1257. DOI: 10.13898/j.cnki.issn.1000-2200.2021.09.027

    血清脂肪酶、淀粉酶及C反应蛋白联合检测对急性胰腺炎诊断的意义

    Significance of combined determination of serum lipase, amylase and C-reactive protein in the diagnosis of acute pancreatitis

    • 摘要:
      目的探讨血清脂肪酶(LPS)、淀粉酶(AMS)及C反应蛋白(CRP)对急性胰腺炎(AP)临床诊断的意义。
      方法采用强生干化学分析仪(VITROS 5600)检测70例AP和30例非AP病人的血清LPS、AMS及CRP水平,对2组数据进行比较分析。
      结果AP组血清LPS、AMS及CRP水平均高于非AP组(P < 0.01),两项指标联合检测的灵敏度和特异度较单项检测都有不同程度的增高,当AMS、LPS、CRP三项指标联合检测时,其诊断的灵敏度达到95.7%,特异度为98.0%,ROC曲线中血清LPS、AMS曲线下面积较高。
      结论血清LPS、AMS及CRP三项联合检测可以有效提高AP的诊断效果,具有很好的临床应用价值。

       

      Abstract:
      ObjectiveTo explore the significance of lipase(LPS), amylase(AMS) and C-reactive protein(CRP) in the diagnosis of acute pancreatitis(AP).
      MethodsThe levels of peripheral blood LPS, AMS and CRP in 70 AP patients and 30 non-AP patients were detected using dry chemical analyzer(VITROS 5600), and the data in two groups were analyzed.
      ResultsThe serum levels of LPS, AMS and CRP in AP group were higher than those in control group(P < 0.01).The sensitivity and specificity of the combined detection of the two indicators were higher than that of the single detection.When the three indicators of AMS, LPS and CRP were combined, the diagnostic sensitivity and specificity of which reached 95.7% and 98.0%, and the area under the ROC curve of serum LPS and AMS was relatively high.
      ConclusionsThe combined detection of serum LPS, AMS and CRP can effectively improve the diagnostic effects of AP, and which is worthy of clinical application.

       

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