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    唐碧, 徐庆梅, 朱飞宇, 莫辰, 张恒, 宣玲, 汤阳, 王闯, 康品方. Cdc42及YAP检测对非瓣膜性心房颤动诊断的相关性研究[J]. 蚌埠医科大学学报, 2021, 46(10): 1349-1353. DOI: 10.13898/j.cnki.issn.1000-2200.2021.10.006
    引用本文: 唐碧, 徐庆梅, 朱飞宇, 莫辰, 张恒, 宣玲, 汤阳, 王闯, 康品方. Cdc42及YAP检测对非瓣膜性心房颤动诊断的相关性研究[J]. 蚌埠医科大学学报, 2021, 46(10): 1349-1353. DOI: 10.13898/j.cnki.issn.1000-2200.2021.10.006
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    TANG Bi, XU Qing-mei, ZHU Fei-yu, MO Chen, ZHANG Heng, XUAN Ling, TANG Yang, WANG Chuang, KANG Pin-fang. Correlation between Cdc42 and YAP in the diagnosis of nonvalvular atrial fibrillation[J]. Journal of Bengbu Medical University, 2021, 46(10): 1349-1353. DOI: 10.13898/j.cnki.issn.1000-2200.2021.10.006
    Citation: TANG Bi, XU Qing-mei, ZHU Fei-yu, MO Chen, ZHANG Heng, XUAN Ling, TANG Yang, WANG Chuang, KANG Pin-fang. Correlation between Cdc42 and YAP in the diagnosis of nonvalvular atrial fibrillation[J]. Journal of Bengbu Medical University, 2021, 46(10): 1349-1353. DOI: 10.13898/j.cnki.issn.1000-2200.2021.10.006
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    Cdc42及YAP检测对非瓣膜性心房颤动诊断的相关性研究

    Correlation between Cdc42 and YAP in the diagnosis of nonvalvular atrial fibrillation

      摘要
    • 摘要:
      目的探讨非瓣膜性心房颤动(房颤)病人血清细胞分裂周期蛋白42(Cdc42)和转录辅助激活因子Yes相关蛋白(YAP)表达水平及临床意义。
      方法选取81例非瓣膜性房颤病人(其中阵发性房颤38例，持续性房颤43例)为研究对象，40例同期住院非房颤病人为对照组，采用酶联免疫吸附法检测血清Cdc42及YAP表达水平。同时结合相关血清学指标，统计分析非瓣膜性房颤病人的Cdc42及YAP水平，探讨两者与非瓣膜性房颤诊断的关系。
      结果同对照组相比，房颤病人CRP、国家标准化比值、D-二聚体、LAD水平增高，LVEF水平降低，差异有统计学意义(P < 0.01)，房颤病人中，持续性房颤病人较阵发性房颤病人LAD增大，LVEF降低，差异有统计学意义(P < 0.01)；同对照组相比，房颤病人血清Cdc42和YAP表达水平增高，差异有统计学意义(P < 0.01)，持续性房颤病人血清Cdc42和YAP表达水平较阵发性房颤病人升高，差异有统计学意义(P < 0.01和P < 0.05)。Pearson相关性分析结果显示，房颤病人血清Cdc42和YAP水平与D-二聚体、LAD呈正相关(P < 0.05~P < 0.01)，与左心室射血分数呈负相关(P < 0.01)；Cdc42及YAP二者联合诊断房颤的受试者工作特征曲线下面积较单独诊断提高(P < 0.05)。D-二聚体、LAD、Cdc42及YAP表达增加、LVEF减小均为影响房颤的危险因素(P < 0.05~P < 0.01)。
      结论房颤病人血清Cdc42及YAP异常表达，可能参与房颤心房结构重构的发生发展，可用作早期潜在辅助诊断房颤的指标。

       

      Abstract:
      ObjectiveTo investigate the serum expression levels of cell division cyclin 42(Cdc42) and transcription-assisted activator Yes-associated protein(YAP) in patients with non-valvular atrial fibrillation, and its clinical significance.
      MethodsEighty-one patients with non-valvular atrial fibrillation(including 38 patients with paroxysmal atrial fibrillation and 43 patients with persistent atrial fibrillation) were selected, and 40 patients with non-atrial fibrillation at the same time were set as the control group.The serum levels of Cdc42 and YAP of patients with non-valvular atrial fibrillation were detected using ELISA, and statistically analyzed in combination with related serological indexes.The relationship between the levels of Cdc42 and YAP and diagnosis of non-valvular atrial fibrillation were investigated.
      ResultsCompared with the control group, the levels of CRP, national standardized ratio, D-dimer and LAD increased, the LVEF level decreased, and the differences of which were statistically significant(P < 0.01).Compared with patients with paroxysmal atrial fibrillation, the level of LAD increased, the level of left ventricular ejection fraction(LVEF) decreased in patients with persistent atrial fibrillation, and the differences of which were statistically significant(P < 0.01).Compared with the control group, the serum levels of Cdc42 and YAP increased in patients with atrial fibrillation, and the differences of which were statistically significant(P < 0.01).Compared with patients with paroxysmal atrial fibrillation, the serum levels of Cdc42 and YAP increased in patients with persistent atrial fibrillation, and the differences of which were statistically significant(P < 0.01).The results of Pearson correlation analysis showed that the serum levels of Cdc42 and YAP were positively correlated with the levels of D-dimer and LAD in patients with atrial fibrillation(P < 0.05 to P < 0.01), and negatively correlated with LVEF(P < 0.01).The area under ROC curve of the combined diagnosis of atrial fibrillation with Cdc42 and YAP was significantly higher than that of the single diagnosis(P < 0.05).The expression levels of D-dimer, LAD, Cdc42 and YAP increasing and LVEF level dereasing were the risk factors of arial fibrillation(P < 0.05 to P < 0.01).
      ConclusionsAbnormal expression of serum Cdc42 and YAP in patients with atrial fibrillation may be involved in the occurrence and development of atrial remodeling in atrial fibrillation, and which can be used as a potential indicator for the early diagnosis of atrial fibrillation.

       

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