Abstract:
ObjectiveTo investigate the serum expression levels of cell division cyclin 42(Cdc42) and transcription-assisted activator Yes-associated protein(YAP) in patients with non-valvular atrial fibrillation, and its clinical significance.
MethodsEighty-one patients with non-valvular atrial fibrillation(including 38 patients with paroxysmal atrial fibrillation and 43 patients with persistent atrial fibrillation) were selected, and 40 patients with non-atrial fibrillation at the same time were set as the control group.The serum levels of Cdc42 and YAP of patients with non-valvular atrial fibrillation were detected using ELISA, and statistically analyzed in combination with related serological indexes.The relationship between the levels of Cdc42 and YAP and diagnosis of non-valvular atrial fibrillation were investigated.
ResultsCompared with the control group, the levels of CRP, national standardized ratio, D-dimer and LAD increased, the LVEF level decreased, and the differences of which were statistically significant(P < 0.01).Compared with patients with paroxysmal atrial fibrillation, the level of LAD increased, the level of left ventricular ejection fraction(LVEF) decreased in patients with persistent atrial fibrillation, and the differences of which were statistically significant(P < 0.01).Compared with the control group, the serum levels of Cdc42 and YAP increased in patients with atrial fibrillation, and the differences of which were statistically significant(P < 0.01).Compared with patients with paroxysmal atrial fibrillation, the serum levels of Cdc42 and YAP increased in patients with persistent atrial fibrillation, and the differences of which were statistically significant(P < 0.01).The results of Pearson correlation analysis showed that the serum levels of Cdc42 and YAP were positively correlated with the levels of D-dimer and LAD in patients with atrial fibrillation(P < 0.05 to P < 0.01), and negatively correlated with LVEF(P < 0.01).The area under ROC curve of the combined diagnosis of atrial fibrillation with Cdc42 and YAP was significantly higher than that of the single diagnosis(P < 0.05).The expression levels of D-dimer, LAD, Cdc42 and YAP increasing and LVEF level dereasing were the risk factors of arial fibrillation(P < 0.05 to P < 0.01).
ConclusionsAbnormal expression of serum Cdc42 and YAP in patients with atrial fibrillation may be involved in the occurrence and development of atrial remodeling in atrial fibrillation, and which can be used as a potential indicator for the early diagnosis of atrial fibrillation.