Solitaire AB支架取栓联合丁苯酞对急性前循环大血管闭塞性卒中病人血清HCY、PLGF及NIHSS评分、mRS评分的影响

杨秀平; 赵尧辉; 冯玉婧; 张志敏; 李雪梅

doi:10.13898/j.cnki.issn.1000-2200.2021.10.013

Solitaire AB支架取栓联合丁苯酞对急性前循环大血管闭塞性卒中病人血清HCY、PLGF及NIHSS评分、mRS评分的影响

Effect of Solitaire AB stent thrombus removal combined with butylphthalide on serum HCY, PLGF, NIHSS scores and mRS scores in patients with acute anterior circulation large vessel occlusive stroke

摘要

摘要:
目的探讨Solitaire AB支架取栓联合丁苯酞氯化钠注射液对急性前循环大血管闭塞性卒中病人血清同型半胱氨酸（homocysteine，HCY）、胎盘生长因子（placental growth factor，PLGF）及美国国立卫生研究院卒中量表（National Institute of Health Stroke Scale，NIHSS）评分、mRS评分的影响。
方法选取急性前循环大血管闭塞性卒中病人120例为研究对象，采取随机数表法将病人分为对照组和观察组，各60例。对照组病人采用Solitaire AB支架取栓治疗，观察组病人在对照组的基础上给予丁苯酞氯化钠注射液，比较2组病人血清HCY、PLGF含量及NIHSS评分、mRS评分。
结果治疗前，2组病人临床病理学资料以及各项指标差异均无统计学意义（P>0.05）；治疗后，观察组病人术后即刻血清HCY表达水平（17.35±5.01）μmol/L，术后14 d表达水平（13.79±3.13）μmol/L，分别低于对照组病人术后即刻表达水平（21.54±4.95）μmol/L和术后14 d表达水平（16.65±4.23）μmol/L（P < 0.01）；观察组病人PLGF术后14 d表达水平（62.35±7.26）ng/L，低于对照组的（79.28±9.13）ng/L（P < 0.01）；治疗后，2组病人NIHSS评分、mRS评分均下降（P < 0.01），其中对照组病人治疗14 d后NIHSS评分为（17.52±3.37）分，高于观察组的（13.28±3.19）分（P < 0.01）；对照组病人mRS评分≤2者占比为28.33%，低于观察组的68.33%（P < 0.01）。
结论 olitaire AB支架取栓联合丁苯酞氯化钠注射液治疗能有效降低急性前循环大血管闭塞性卒中病人血清HCY表达水平、PLGF水平和病人NIHSS、mRS评分，提高临床疗效。

Abstract:
Objective To explore the effects of Solitaire AB stent thrombus removal combined with butylphthalide sodium chloride injection on serum HCY, PLGF, NIHSS score and mRS score in patients with acute anterior circulation large vessel occlusive stroke.
Methods A total of 120 patients with acute anterior circulation cerebral infarction were selected as the experimental subjects of the study.The patients were divided into the control group and observation group by random number table method, with 60 cases in each group.Patients in the control group were treated with Solitaire AB stent thrombus removal.Patients in the observation group were given butylphthalide sodium chloride injection on the basis of the control group.Serum HCY, PLGF and NIHSS score and mRS score were compared between the two groups.
Results Before treatment, there was no significant difference in the clinical pathological data of the two groups of patients and the comparison of various indicators in this study.After treatment, the serum HCY level in the observation group immediately after surgery was(17.35±5.01) μmol/L, the level of HCY on the 14th day after operation was (13.79±3.13) μmol/L, the immediate level of HCY in the control group was(21.54±4.95) μmol/L and the level of HCY on the 14th day after operation was(16.65±4.23) μmol/L.The improvement of the observation group was significantly better than that of the control group (P < 0.01).The PLGF level of patients in the observation group was(79.28±9.13) ng/L at 14 days after operation.The PLGF level in the observation group was(62.35±7.26) ng/L, and the PLGF level in the observation group was significantly better than that of the control group.The NIHSS score and mRS score in the two groups were decreased(P < 0.01).After 14 days of treatment, the NIHSS score in the control group was(17.52±3.37), which was higher than that in the observation group(13.28±3.19) (P < 0.01).The proportion of patients with mRS score ≤ 2 in the control group was 28.33%, which was lower than 68.33% in the observation group(P < 0.01).
Conclusions Solitaire AB stent thrombus removal combined with butylphthalide sodium chloride injection can effectively increase the serum HCY expression level and reduce the PLGF level, the patient's NIHSS and mRS scores in patients with acute anterior circulation large vessel occlusive stroke, which can improve the clinical efficacy.

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