丙种球蛋白结合高压氧对病毒性脑炎患儿的康复效果

回立远; 韩冰; 王芳; 赵丽静; 范雪爱

doi:10.13898/j.cnki.issn.1000-2200.2021.10.014

丙种球蛋白结合高压氧对病毒性脑炎患儿的康复效果

Effect of hyperbaric oxygen combined with r-globulin on the rehabilitation of viral encephalitis children

摘要

摘要:
目的探究高压氧结合丙种球蛋白对病毒性脑炎（VE）患儿的康复效果及对β-内啡肽（β-EP）、髓鞘碱性蛋白（MBP）和心肌酶谱水平的影响。
方法 110例VE患儿采用随机数字表法分为观察组55例和对照组55例。对照组患儿给予丙球蛋白进行治疗，观察组给予高压氧联合丙球蛋白进行治疗。观察2组患儿的临床疗效、临床症状缓解时间，β-EP、MBP及心肌酶谱水平，以及后遗症的发生率。
结果观察组患儿的治疗有效率为90.91%，显著高于对照组患儿72.73%（P < 0.01）；观察组患儿的退热、头痛、恶心呕吐以及意识清醒缓解时间等方面均显著短于对照组（P < 0.01）；另外，治疗后，2组患儿血清中的β-EP和MBP水平均显著下降（P < 0.01），且观察组病人水平显著低于对照组（P < 0.01）；治疗后，2组病人血清中LDH、CK、CK-MB及AST水平均显著降低（P < 0.01），并且观察组病人水平显著低于对照组（P < 0.01）；观察组患儿后遗症发生率仅为9.01%且显著低于对照组的23.64%（P < 0.05）。
结论高压氧结合丙种球蛋白能够有效治疗病毒性脑炎患儿，通过降低患儿β-EP、MBP及心肌酶谱水平，改善病人神经功能，降低后遗症的发生率，值得在临床上推广。

Abstract:
Objective To explore the effects of hyperbaric oxygen combined with r-globulin on the rehabilitation and levels of β-endorphin(β-EP), myelin basic protein(MBP) and myocardial enzyme spectrum in children with viral encephalitis(VE).
Methods One hundred and ten children with VE were divided into the observation group and control group using random number table method(55 cases in each group).The control group was treated with r-globulin, while the observation group was treated with hyperbaric oxygen combined with r-globulin.The clinical efficacy, clinical symptom, relief time, levels of β-EP, MBP and myocardial enzyme spectrum, and incidence rate of sequelae were observed in two groups.
Results The therapeutic efficiency in observation group(90.91%) was significantly higher than that in control group(72.73%) (P < 0.01).The remission time of fever, headache, nausea and vomiting and consciousness in observation group were significantly lower than those in control group(P < 0.01).After treatment, the serum levels of β-EP and MBP in two groups significantly decreased(P < 0.01), and which in observation group were significantly lower than those in control group(P < 0.01).After treatment, the serum levels of LDH、CK、CK-MB and AST in two groups significantly decreased(P < 0.01), and which in observation group were significantly lower than those in control group(P < 0.01).The incidence rate of sequelae in observation group(9.01%) was significantly lower than that in control group(23.64%) (P < 0.05).
Conclusions Hyperbaric oxygen combined with r-globulin can effectively treat the VE.The neurologic function can be improved, and the incidence rate of sequelae can be reduced by decreasing the levels of β-EP, MBP and myocardial enzyme in VE children.It is worthy of clinical promotion.

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