刘翠, 薛成俊, 吴旭东. 早期胃癌及癌前病变ESD术后出血的影响因素研究[J]. 蚌埠医学院学报, 2021, 46(11): 1513-1516. DOI: 10.13898/j.cnki.issn.1000-2200.2021.11.005
    引用本文: 刘翠, 薛成俊, 吴旭东. 早期胃癌及癌前病变ESD术后出血的影响因素研究[J]. 蚌埠医学院学报, 2021, 46(11): 1513-1516. DOI: 10.13898/j.cnki.issn.1000-2200.2021.11.005
    LIU Cui, XUE Cheng-jun, WU Xu-dong. Study on the influencing factors of hemorrhage after ESD for early gastric cancer and precancerous lesions[J]. Journal of Bengbu Medical College, 2021, 46(11): 1513-1516. DOI: 10.13898/j.cnki.issn.1000-2200.2021.11.005
    Citation: LIU Cui, XUE Cheng-jun, WU Xu-dong. Study on the influencing factors of hemorrhage after ESD for early gastric cancer and precancerous lesions[J]. Journal of Bengbu Medical College, 2021, 46(11): 1513-1516. DOI: 10.13898/j.cnki.issn.1000-2200.2021.11.005

    早期胃癌及癌前病变ESD术后出血的影响因素研究

    Study on the influencing factors of hemorrhage after ESD for early gastric cancer and precancerous lesions

    • 摘要:
      目的研究早期胃癌及癌前病变经内镜黏膜下剥离术(ESD)术后出血的影响因素。
      方法纳入2017年1月至2019年9月86例行ESD治疗早期胃癌及癌前病变病人为研究对象,所有病人均接受ESD治疗,观察早期胃癌及癌前病变病人ESD治疗后出血发生情况,并统计病人一般资料及实验室检查指标,采用多因素logistic回归分析法分析早期胃癌及癌前病变病人ESD治疗后出血的独立影响因素。
      结果86例经ESD治疗病人中,16例病人发生出血(18.60%);70例病人未出血,占81.40%。多因素logistic回归分析显示,病变部位为贲门-胃底(OR=3.714,95% CI=1.252~10.909)、肿瘤大小≥ 3 cm(OR=3.802,95% CI=1.538~9.646)、病理类型为早期癌(OR=2.746,95% CI=1.133~6.867)是早期胃癌及癌前病变ESD术后出血的独立危险因素(P < 0.05~P < 0.01)。
      结论早期胃癌及癌前病变病人经ESD治疗出血与病变部位、肿瘤大小、病理类型有关,肿瘤越大、病变位于贲门-胃底和早期胃癌治疗时更容易发生出血。

       

      Abstract:
      ObjectiveTo study the influencing factors of hemorrhage after endoscopic submucosal dissection(ESD) for early gastric cancer and precancerous lesions.
      MethodsEighty-six patients with early gastric cancer and precancerous lesions treated with ESD from January 2017 to September 2019 were investigated.All patients were treated with ESD.The occurrence of hemorrhage in patients with early gastric cancer and precancerous lesions after ESD were observed, and the general data and laboratory examination indexes of patients were counted.The independent influencing factors of hemorrhage in patients with early gastric cancer and precancerous lesions after ESD were analyzed using multivariate logistic regression analysis.
      ResultsAmong the 86 patients treated with ESD, 16 patients, accounting for 18.60%, experienced hemorrhage.There was no hemorrhage in 70 patients, accounting for 81.40%.The results of multivariate logistic regression analysis showed that the lesion location for cardia-gastric fundus(OR=3.714, 95% CI=1.252-10.909), tumor size ≥ 3 cm(OR=3.802, 95% CI=1.538-9.646), and early cancer(OR=2.746, 95% CI=1.133-6.867) were the independent risk factors of hemorrhage after ESD for early gastric cancer and precancerous lesions(P < 0.05 to P < 0.01).
      ConclusionsThe hemorrhage of patients with early gastric cancer and precancerous lesions after ESD is related to the location, size and pathological type of the lesion.The larger tumors, lesions locating in the cardia-gastric fundus and early gastric cancer are more prone to hemorrhage during treatment.

       

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