ObjectiveTo investigate the risk factors of nosocomial infection in peritoneal dialysis(PD) patients with chronic renal failure.

MethodsThe clinical data of 193 PD patients with chronic renal failure were retrospectively analyzed, and divided into the infection group and non-infection group according to whether occurrence of nosocomial infection.The nosocomial infection situation and distribution of pathogenic bacteria in two groups were analyzed.The clinical data were compared between two groups, and the risk factors of nosocomial infection in PD patients were analyzed using multivariate logistic analysis.

ResultsFifty-two PD patients(21.76%) with nosocomial infection were found, which included 17 cases with respiratory tract infections(8.81%) and 10 cases with urinary tract infections(5.18%).A total of 56 strains pathogenic bacteria were cultured, which included 44 strains of gram-negative strains(78.57%) and 5 strains of gram-positive strains(8.93%).The differences of the age, length of hospital stay, dialysis duration, hypoproteinemia, body mass index(BMI), anemia, cardiac insufficiency, full hemodialysis and central venous catheter application between two groups group were statistically significant(P < 0.05 to P < 0.01).The age, length of hospital stay, length of dialysis, hypoproteinemia, BMI, anemia, cardiac insufficiency, adequate hemodialysis and use of central venous catheter were the independent risk factors of nosocomial infection(P < 0.01).

ConclusionsThe respiratory tract infection and Klebsiella pneumoniae are the most common nosocomial infections in PD patients with chronic renal failure.Clinical attention should be paid to PD patients with advanced age, long hospitalization, dialysis, hypoproteinemia, anemia and cardiac insufficiency to prevent nosocomial infections.