乔德丽, 山岚, 吴红耀, 冯景, 凌莹. 营养不良-炎症状态对老年血液透析病人生存质量影响[J]. 蚌埠医学院学报, 2022, 47(2): 184-187. DOI: 10.13898/j.cnki.issn.1000-2200.2022.02.011
    引用本文: 乔德丽, 山岚, 吴红耀, 冯景, 凌莹. 营养不良-炎症状态对老年血液透析病人生存质量影响[J]. 蚌埠医学院学报, 2022, 47(2): 184-187. DOI: 10.13898/j.cnki.issn.1000-2200.2022.02.011
    QIAO De-li, SHAN Lan, WU Hong-yao, FENG Jing, LING Ying. Effect of malnutrition-inflammation status on the quality of life of elderly hemodialysis patients[J]. Journal of Bengbu Medical College, 2022, 47(2): 184-187. DOI: 10.13898/j.cnki.issn.1000-2200.2022.02.011
    Citation: QIAO De-li, SHAN Lan, WU Hong-yao, FENG Jing, LING Ying. Effect of malnutrition-inflammation status on the quality of life of elderly hemodialysis patients[J]. Journal of Bengbu Medical College, 2022, 47(2): 184-187. DOI: 10.13898/j.cnki.issn.1000-2200.2022.02.011

    营养不良-炎症状态对老年血液透析病人生存质量影响

    Effect of malnutrition-inflammation status on the quality of life of elderly hemodialysis patients

    • 摘要:
      目的探讨老年血液透析病人营养不良-炎症状态与生存质量关系。
      方法选取老年血液透析病人103例,分别采用营养不良-炎症评分法(MIS)和肾病生存质量专用量表(KDQOL-SFTM)进行调查,其结果与临床营养、炎症指标C反应蛋白(CRP)、白细胞介素-6(IL-6)、体质量指数(BMI)、前白蛋白(ALB)、血红蛋白进行相关性分析和多元线性分析,探索影响生存质量因素。
      结果MIS评分结果:营养不良发生率为83.5%(86/103);KDQOL-SFTM评分结果:肾病、透析相关生存质量(KDTA)为(52.86±9.65),一般健康相关生存质量(SF-36)为(48.74±16.32);相关性分析显示SF-36评分与CRP、IL-6、MIS评分、透析史呈负相关(P < 0.05~P < 0.01),与BMI呈正相关(P < 0.01);KDTA评分与CRP和年龄呈负相关(P < 0.01和P < 0.05),与ALB呈正相关(P < 0.01);多元线性回归分析显示,随着BMI值增高、IL-6和MIS降低,SF-36增高;随着CRP降低、ALB增高,KDTA总评分增高(P < 0.05~P < 0.01)。
      结论老年血液透析病人营养不良发生率较高,而生存质量水平较低;BMI、IL-6、MIS是SF-36重要影响因素;CRP、ALB是KDTA重要影响因素。积极纠正营养不良-炎症状态有利于改善病人生存质量。

       

      Abstract:
      ObjectiveTo investigate the relationship between malnutrition-inflammatory status and quality of life in elderly hemodialysis patients.
      MethodsOne hundred and three elderly patients with hemodialysis were investigated using malnutrition inflammation score(MIS) combined with kidney disease quality of life short form(KDQOL-SFTM), and the relationship between the results of which and clinical nutritional, inflammatory indicatorsC reactive protein(CRP), interleukin-6(IL-6), body mass index(BMI), albumin(ALB), hemoglobin were analyzed using the correlation and multivariate linear analysis to explore the influencing factors of quality of life.
      ResultsThe results of MIS showed that the incidence rate of malnutrition was 83.5%(86/103).The results of ADQOL-SFTM showed that the score of kidney disease-targeted areas(KDTA) was(52.86±9.65), and the score of short form health survey questionnaire 36(SF-36) was(48.74±16.32).The results of correlation analysis showed that the SF-36 score was positively correlated with BMI score(P < 0.01), and negatively correlated with the scores of CRP, IL-6 and MIS(P < 0.05 to P < 0.01).The KDTA score was positively correlated with ALB score(P < 0.01), and negatively correlated with the scores of CRP and age(P < 0.01 and P < 0.05).The results of multiple linear regression analysis showed that the SF-36 score increased, and the scores of IL-6 and MIS decreased with the increasing of BMI.With the decreasing of CRP, the score of ALB increased, and the total KDTA score increased(P < 0.05 to P < 0.01).
      ConclusionsThe incidence rate of malnutrition in elderly hemodialysis patients is higher, and the quality of life is lower.The BMI, IL-6 and MIS are important influencing factors of SF-36, and the CRP and ALB are important influencing factors of KDTA.Correcting the state of malnutrition and inflammation is helpful to improve the quality of life of patients.

       

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