鲁婷, 郭敏娜, 韩传宝, 李竞进. 酒石酸布托啡诺复合氟比洛芬酯用于腹腔镜子宫切除病人术后镇痛的效果[J]. 蚌埠医学院学报, 2022, 47(4): 462-465. DOI: 10.13898/j.cnki.issn.1000-2200.2022.04.009
    引用本文: 鲁婷, 郭敏娜, 韩传宝, 李竞进. 酒石酸布托啡诺复合氟比洛芬酯用于腹腔镜子宫切除病人术后镇痛的效果[J]. 蚌埠医学院学报, 2022, 47(4): 462-465. DOI: 10.13898/j.cnki.issn.1000-2200.2022.04.009
    LU Ting, GUO Min-na, HAN Chuan-bao, LI Jing-jin. Effect of butorphanol tartrate combined with flurbiprofen ester on the postoperative analgesia in patients treated with laparoscopic hysterectomy[J]. Journal of Bengbu Medical College, 2022, 47(4): 462-465. DOI: 10.13898/j.cnki.issn.1000-2200.2022.04.009
    Citation: LU Ting, GUO Min-na, HAN Chuan-bao, LI Jing-jin. Effect of butorphanol tartrate combined with flurbiprofen ester on the postoperative analgesia in patients treated with laparoscopic hysterectomy[J]. Journal of Bengbu Medical College, 2022, 47(4): 462-465. DOI: 10.13898/j.cnki.issn.1000-2200.2022.04.009

    酒石酸布托啡诺复合氟比洛芬酯用于腹腔镜子宫切除病人术后镇痛的效果

    Effect of butorphanol tartrate combined with flurbiprofen ester on the postoperative analgesia in patients treated with laparoscopic hysterectomy

    • 摘要:
      目的观察酒石酸布托啡诺复合氟比洛芬酯用于腹腔镜子宫切除病人术后镇痛效果的研究。
      方法将行腹腔镜子宫切除的200例女性病人,按照随机数字表分为2组:观察组(PB组),手术结束前30 min静脉注射布托啡诺20 μg/kg,连接PCIA泵(配方:布托啡诺12 mg+盐水格拉司琼注射液6 mg);对照组(F组),手术结束前30 min静脉注射芬太尼1 μg/kg,连接PCIA泵(配方:芬太尼0.6 mg+盐水格拉司琼注射液6 mg)。2组均将镇痛泵制药业稀释至总量100 mL。2组病人切片前均静脉注射氟比洛芬酯50 mg。记录术中血流动力学的变化。记录术后1 h(T1)、术后6 h(T2)、术后24 h(T3)、术后48 h(T4)的切口疼痛评分、内脏疼痛评分及镇静评分。记录术后补充镇痛药次数和PCIA按压次数。同时记录术后恶心、呕吐、皮肤瘙痒、呼吸抑制和心动过缓的不良反应情况。
      结果2组术中血流动力学变化差异无统计学意义(P>0.05)。PB组T1、T2、T3腹内脏疼痛VAS评分均明显低于F组(P < 0.01),术后T1、T2、T3和T4 Ramsay镇静评分均高于F组(P < 0.05~P < 0.01);PB组术后PCIA按压次数少于F组,不良反应低于F组(P < 0.01)。
      结论酒石酸布托啡诺复合氟比洛芬酯能明显减轻腹腔镜子宫切除病人的内脏痛,有较好的镇静作用,且不良反应发生率低。

       

      Abstract:
      ObjectiveTo observe the effects of butorphanol tartrate combined with flurbiprofen ester on the postoperative analgesia in patients treated with laparoscopic hysterectomy.
      MethodsTwo hundred female patients treated with laparoscopic hysterectomy were divided into the experimental group(group PB) and control group(group F) according to the random table method.Before 30 min of the end of surgery, the group PB was intravenously injected with 20 μg/kg of butorphanol, and connected with PCIA pump(formula: 12 mg butorphanol+6 mg granisetron injection), and the group F were intravenously injected with 1 μg/kg of fentanyl, and connected with PCIA pump(formula: 0.6 mg fentanyl + 6 mg granisetron injection).The volume of analgesia pump was diluted to 100 mL in two groups.Two groups were intravenously injected with 50 mg flurbiprofen ester before surgical incision.The intraoperative hemodynamic changes in two groups were recorded.The incision pain score, visceral pain score and sedation score in two groups after 1 h(T1), 6 h(T2), 24 h(T3) and 48 h(T4) of operation were recorded.The times of adding analgesics and pressing PCIA were recorded after operation.The postoperative nausea, vomiting, skin pruritus, respiratory depression and bradycardia were also recorded in two groups.
      ResultsThere was no statistical significance in hemodynamic changes between two groups(P>0.05).The visceral pain scores in group PB at T1, T2 and T3 were significantly lower than those in group F(P < 0.01), and the Ramsay scores in group PB at T1, T2, T3 and T4 were higher than those in group F(P < 0.05 to P < 0.01).The times of pressing PCIA and postoperative adverse reactions in PB group were lower than those in group F(P < 0.01).
      ConclusionsButorphanol tartrate combined with flurbiprofen ester can significantly relieve visceral pain in patients treated with laparoscopic hysterectomy, and has a good sedative effect with a low incidence of adverse reactions.

       

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