ObjectiveTo observe the effects of butorphanol tartrate combined with flurbiprofen ester on the postoperative analgesia in patients treated with laparoscopic hysterectomy.

MethodsTwo hundred female patients treated with laparoscopic hysterectomy were divided into the experimental group(group PB) and control group(group F) according to the random table method.Before 30 min of the end of surgery, the group PB was intravenously injected with 20 μg/kg of butorphanol, and connected with PCIA pump(formula: 12 mg butorphanol+6 mg granisetron injection), and the group F were intravenously injected with 1 μg/kg of fentanyl, and connected with PCIA pump(formula: 0.6 mg fentanyl + 6 mg granisetron injection).The volume of analgesia pump was diluted to 100 mL in two groups.Two groups were intravenously injected with 50 mg flurbiprofen ester before surgical incision.The intraoperative hemodynamic changes in two groups were recorded.The incision pain score, visceral pain score and sedation score in two groups after 1 h(T₁), 6 h(T₂), 24 h(T₃) and 48 h(T₄) of operation were recorded.The times of adding analgesics and pressing PCIA were recorded after operation.The postoperative nausea, vomiting, skin pruritus, respiratory depression and bradycardia were also recorded in two groups.

ResultsThere was no statistical significance in hemodynamic changes between two groups(P>0.05).The visceral pain scores in group PB at T₁, T₂ and T₃ were significantly lower than those in group F(P < 0.01), and the Ramsay scores in group PB at T₁, T₂, T₃ and T₄ were higher than those in group F(P < 0.05 to P < 0.01).The times of pressing PCIA and postoperative adverse reactions in PB group were lower than those in group F(P < 0.01).

ConclusionsButorphanol tartrate combined with flurbiprofen ester can significantly relieve visceral pain in patients treated with laparoscopic hysterectomy, and has a good sedative effect with a low incidence of adverse reactions.