嗜酸性粒细胞百分比和干扰素-γ用于支气管扩张伴支气管哮喘的诊断效能分析

刘红红; 邢宁宁; 师丽敏; 李爱军

doi:10.13898/j.cnki.issn.1000-2200.2022.04.019

嗜酸性粒细胞百分比和干扰素-γ用于支气管扩张伴支气管哮喘的诊断效能分析

Analysis of the diagnostic efficacy of eosinophil percentage and interferon-γ in bronchiectasis with asthma

摘要

摘要:
目的探讨嗜酸性粒细胞百分比(EOS%)和干扰素-γ(IFN-γ)对支气管扩张伴支气管哮喘的诊断价值。
方法选择支气管哮喘或者支气管扩张病人共165例，其中支气管扩张合并哮喘为A组48例，单纯哮喘为B组60例，单纯支气管扩张为C组57例。收集病人的临床资料，检测白细胞(WBC)、C反应蛋白(CRP)、降钙素原(PCT)、氧分压(PO₂)、二氧化碳分压(PCO₂)、EOS%和IFN-γ的水平，运用logistic回归拟合IFN-γ、EOS%联合诊断模型并绘制ROC曲线评估诊断价值，采用Hanley-McNeil方法比较ROC曲线下面积。
结果A组、B组病人EOS%明显高于C组(P < 0.01)，A组、B组病人EOS%差异无统计学意义(P>0.05)，A组病人IFN-γ低于B组、C组(P < 0.01)。EOS%诊断支气管扩张合并哮喘的敏感性为0.684，特异性为0.621；IFN-γ诊断支气管扩张合并哮喘的敏感性为0.614，特异性为0.661；IFN-γ联合EOS%诊断支气管扩张合并哮喘的敏感性为0.754，特异性为0.601。
结论EOS%联合IFN-γ诊断支气管扩张合并哮喘的敏感性和特异性均较高，诊断价值较高。

Abstract:
ObjectiveTo investigate the diagnostic value of eosinophil percentage(EOS%) and interferon-γ(IFN-γ) in bronchiectasis with asthma.
MethodsA total of 165 patients with asthma or bronchiectasis were selected, including 48 patients with bronchiectasis combined with asthma in group A, 60 patients with asthma alone in group B, and 57 patients with bronchiectasis alone in group C.The clinical data of patients were collected, WBC, CRP, PCT, PO₂, pCO₂, EOS% and IFN-γ levels were measured and analyzed.Logistic regression was used to fit the IFN-γ and EOS% joint diagnosis model and draw the ROC curve to evaluate the diagnostic value.The area under the ROC curve was compared by Hanley-McNeil method.
ResultsEOS% in group A and group B was significantly higher than that in group C(P < 0.01), and there was no significant difference in EOS% between group A and group B(P>0.05).IFN-γ in group A was significantly lower than that in group B and group C(P < 0.01).The sensitivity of EOS% in the diagnosis of bronchiectasis with asthma was 0.684, the specificity was 0.621;the sensitivity of IFN-γ in the diagnosis of bronchiectasis with asthma was 0.614, the specificity was 0.661.The sensitivity and specificity of IFN-γ combined with EOS% in the diagnosis of bronchiectasis with asthma were 0.754 and 0.601, respectively.
ConclusionsThe sensitivity and specificity of EOS% combined with IFN-γ in the diagnosis of bronchiectasis combined with asthma are high, which has high diagnosis value.

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