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    李大勇, 李光耀, 蔡娟. PLR和PNI联合评分预测胃癌预后的评估价值[J]. 蚌埠医科大学学报, 2022, 47(9): 1199-1203. DOI: 10.13898/j.cnki.issn.1000-2200.2022.09.011
    引用本文: 李大勇, 李光耀, 蔡娟. PLR和PNI联合评分预测胃癌预后的评估价值[J]. 蚌埠医科大学学报, 2022, 47(9): 1199-1203. DOI: 10.13898/j.cnki.issn.1000-2200.2022.09.011
    shu
    LI Da-yong, LI Guang-yao, CAI Juan. Value of PLR combined with PNI score in predicting the prognosis of gastric cancer[J]. Journal of Bengbu Medical University, 2022, 47(9): 1199-1203. DOI: 10.13898/j.cnki.issn.1000-2200.2022.09.011
    Citation: LI Da-yong, LI Guang-yao, CAI Juan. Value of PLR combined with PNI score in predicting the prognosis of gastric cancer[J]. Journal of Bengbu Medical University, 2022, 47(9): 1199-1203. DOI: 10.13898/j.cnki.issn.1000-2200.2022.09.011
    shu

    PLR和PNI联合评分预测胃癌预后的评估价值

    Value of PLR combined with PNI score in predicting the prognosis of gastric cancer

      摘要
    • 摘要:
      目的评估基于术前血小板与淋巴细胞比值(PLR)和预后营养指数(PNI)建立的PLR-PNI评分对胃癌病人预后的评估价值。
      方法回顾性分析171例行胃癌根治术病人的临床资料，通过受试者工作特征曲线(ROC)根据5年生存率确定PLR、PNI的最佳临界值。根据临界值分为高PLR组(PLR≥148，1分)和低PLR组(PLR < 148, 0分)，高PNI组(PNI≥47, 0分)和低PNI组(PNI < 47, 1分)。评估不同评分病人预后情况。
      结果PLR-PNI=2的病人，5年总生存率低于PLR-PNI = 1或0的病人(11.36% vs 32.79或63.64，P < 0.05)。多因素分析显示，肿瘤分化差、TNM分期晚、PLR-PNI评分高是影响胃癌病人术后预后的独立危险因素(P < 0.01)。
      结论术前高PLR-PNI是预测胃癌不良预后的独立因素，该评分系统可应用于临床以识别高危病人。

       

      Abstract:
      ObjectiveTo evaluate the value of platelet/lymphocyte ratio (PLR)-prognostic nutritional index (PNI) score based on preoperative PLR and PNI in predicting the prognosis of patients with gastric cancer.
      MethodsThe clinical data of 171 patients undergoing radical gastrectomy for gastric cancer were analyzed retrospectively, and the optimal cut-off values of PLR and PNI were determined according to the 5-year survival rate through the receiver operating characteristic (ROC) curve.According to the cut-off value, they were divided into high PLR group (PLR≥148, 1 point) and low PLR group (PLR < 148, 0 point), high PNI group (PNI ≥47, 0 point) and low PNI group (PNI < 47, 1 point).The prognosis of patients with different scores was evaluated.
      ResultsThe 5-year overall survival rate of patients with PLR-PNI value of 2 was lower than that of patients with PLR-PNI value of 1 or 0 (11.36% vs 32.79 or 63.64, P < 0.05).Multivariate analysis showed that poor tumor differentiation, late TNM staging, and high PLR-PNI score were independent risk factors for postoperative prognosis of patients with gastric cancer (P < 0.01).
      ConclusionsPreoperative high PLR-PNI is an independent factor to predict the poor prognosis of gastric cancer.Thus, the scoring system can be used to differentiate high-risk patients in clinical work.

       

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