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    耿旭, 周开恩, 李倩, 梁子舜, 金娟, 李晨源, 陈天平. 2型糖尿病合并冠心病病人冠状动脉病变程度和MDA及SOD的相关性研究[J]. 蚌埠医科大学学报, 2022, 47(9): 1214-1216. DOI: 10.13898/j.cnki.issn.1000-2200.2022.09.015
    引用本文: 耿旭, 周开恩, 李倩, 梁子舜, 金娟, 李晨源, 陈天平. 2型糖尿病合并冠心病病人冠状动脉病变程度和MDA及SOD的相关性研究[J]. 蚌埠医科大学学报, 2022, 47(9): 1214-1216. DOI: 10.13898/j.cnki.issn.1000-2200.2022.09.015
    shu
    GENG Xu, ZHOU Kai-en, LI Qian, LIANG Zi-shun, JIN Juan, LI Chen-yuan, CHEN Tian-ping. Correlation between the degree of coronary artery disease and MDA and SOD in patients with type 2 diabetes mellitus complicated with coronary heart disease[J]. Journal of Bengbu Medical University, 2022, 47(9): 1214-1216. DOI: 10.13898/j.cnki.issn.1000-2200.2022.09.015
    Citation: GENG Xu, ZHOU Kai-en, LI Qian, LIANG Zi-shun, JIN Juan, LI Chen-yuan, CHEN Tian-ping. Correlation between the degree of coronary artery disease and MDA and SOD in patients with type 2 diabetes mellitus complicated with coronary heart disease[J]. Journal of Bengbu Medical University, 2022, 47(9): 1214-1216. DOI: 10.13898/j.cnki.issn.1000-2200.2022.09.015
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    2型糖尿病合并冠心病病人冠状动脉病变程度和MDA及SOD的相关性研究

    Correlation between the degree of coronary artery disease and MDA and SOD in patients with type 2 diabetes mellitus complicated with coronary heart disease

      摘要
    • 摘要:
      目的探索2型糖尿病(T2DM)合并冠心病(CHD)病人的冠状动脉病变特点，分析不同冠状动脉病变支数与氧化应激水平的相关性。
      方法选择接受冠状动脉造影的病人198例，根据是否有T2DM病史分为T2DM合并CHD组65例和CHD组133例，检测2组临床相关指标，根据冠状动脉造影结果分析不同冠状动脉病变支数与丙二醛(MDA)及超氧化物歧化酶(SOD)的相关性。
      结果T2DM合并CHD组MDA水平明显高于CHD组(P < 0.01)，SOD水平低于CHD组(P < 0.05)，2支及以上冠状动脉病变比例高于单纯CHD组(P < 0.01)；T2DM合并CHD组病人中，1支冠状动脉病变组SOD水平高于2支及以上冠状动脉病变组，MDA水平低于2支及以上冠状动脉病变组(P < 0.01)。
      结论T2DM合并CHD组病人氧化应激水平高于单纯CHD组，且冠状动脉病变加重；随着T2DM合并CHD病人冠状动脉病变支数加重，氧化应激水平升高。

       

      Abstract:
      ObjectiveTo explore the characteristics of coronary artery lesions in patients with type 2 diabetes mellitus (T2DM) complicated with coronary heart disease (CHD), and to analyze the correlation between the number of coronary artery lesions and the level of oxidative stress.
      MethodsA total of 198 patients who underwent coronary angiography were divided into two groups according to whether they had T2DM history: 65 patients in T2DM combined with CHD group and 133 patients in CHD group.The clinic-related indexes of the two groups were measured.The correlation between the number of different coronary artery lesions and malondialdehyde (MDA) and superoxide dismutase (SOD) was analyzed according to the results of coronary angiography.
      ResultsThe level of MDA in the T2DM combined with CHD group was higher than that in the CHD group (P < 0.01), that and the level of SOD was lower than that in the CHD group (P < 0.05).The proportion of two or more coronary artery lesions in the T2DM group with CHD was higher than that in the CHD group(P < 0.01).In the T2DM combined with CHD group, the level of SOD in the group with one coronary artery lesion was higher than that in the group with two or more coronary artery lesions, and the level of MDA was lower than that in the group with two or more coronary artery lesions (P < 0.01).
      ConclusionsThe oxidative stress level of T2DM patients with CHD is higher than that of CHD alone, and the coronary artery disease is more severe.The oxidative stress level increases with the aggravation of the number of coronary artery lesions.

       

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