血清同型半胱氨酸及25(OH)D在糖尿病周围神经病变伴抑郁状态病人中的表达及意义

邵蔚; 梁进; 宋春侠; 罗玲

doi:10.13898/j.cnki.issn.1000-2200.2022.09.018

血清同型半胱氨酸及25(OH)D在糖尿病周围神经病变伴抑郁状态病人中的表达及意义

Expression and significance of serum homocysteine and 25(OH)D in patients with diabetic peripheral neuropathy and depression

摘要

摘要:
目的探究血清同型半胱氨酸(Hcy)及25羟维生素D25(OH)D在糖尿病周围神经病变(diabetic peripheral neuropathy，DPN)伴抑郁状态病人中的表达及意义。
方法回顾性分析80例DPN伴抑郁病人的临床资料，将其作为DPN伴抑郁组，选取60例DPN未伴随抑郁状态的病人作为DPN组，另选取50名同期来本院进行健康体检的人群为对照组。依据汉密尔顿抑郁量表(Hamilton depression scale，HAMD)评分将80例DPN伴抑郁病人分为轻度抑郁、中度抑郁与重度抑郁，分别为32例、27例、21例。对比不同组别病人Hcy、25(OH)D水平的表达水平，分析Hcy、25(OH)D水平与DPN是否伴抑郁症状的相关性。
结果DPN伴抑郁组病人Hcy水平明显高于DPN组与对照组，25(OH)D水平明显低于DPN组与对照组；DPN组病人Hcy水平明显高于对照组，25(OH)D水平明显低于对照组(P < 0.01)。重度抑郁组病人Hcy水平明显高于中度抑郁与轻度抑郁组，25(OH)D水平明显低于中度抑郁与轻度抑郁组；中度抑郁组Hcy水平明显高于轻度抑郁组，25(OH)D水平低于轻度抑郁组(P < 0.05~P < 0.01)。Pearson相关性分析结果表明，Hcy水平与DPN是否伴抑郁症状呈明显正相关关系(P < 0.01)，25(OH)D水平与DPN是否伴抑郁症状呈明显负相关关系(P < 0.01)。
结论Hcy水平的升高与25(OH)D水平的降低与DPN伴抑郁症状的发生及抑郁严重程度有关，需引起临床的重视。

Abstract:
ObjectiveTo explore the expression and significance of serum homocysteine (Hcy) and 25 hydroxy vitamin D 25(OH)D in patients with diabetic peripheral neuropathy (DPN) and depression.
MethodsThe clinical data of 80 patients with DPN and depression were retrospectively analyzed, and they were taken as DPN with depression group, and 60 DPN patients without depression were selected as DPN group, another 50 people undergoing health checkup during the same period were selected as control group.According to the Hamilton depression scale (HAMD) score, 80 patients with DPN and depression were divided into mild depression (32 cases), moderate depression (27 cases) and severe depression (21 cases).The expression levels of Hcy and 25(OH)D in different groups of patients were compared.The correlation between Hcy and 25(OH)D levels and whether DPN was associated with depressive symptoms was analyzed by Pearson correlation.
ResultsThe level of Hcy in the DPN with depression group was significantly higher than that in the DPN group and the control group, and the level of 25(OH)D was significantly lower than that in the DPN group and the control group; the level of Hcy in the DPN group was significantly higher than that in the control group, and the level of 25(OH)D was significantly lower than that in the control group (P < 0.01).The Hcy level in the severe depression group was significantly higher than that in the moderate and mild depression groups, and the 25(OH)D level was significantly lower than that in the moderate and mild depression groups; the Hcy level in the moderate depression group was significantly higher than that in the mild depression group, and the level of 25(OH)D was lower than that in the mild depression group (P < 0.05 to P < 0.01).The Pearson correlation analysis showed that the level of Hcy was significantly positively correlated with whether DPN was associated with depressive symptoms (P < 0.01), and the level of 25(OH)D was significantly negatively correlated with whether DPN was associated with depressive symptoms (P < 0.01).
ConclusionsThe increase of Hcy level and the decrease of 25(OH)D level are related to the occurrence of DPN with depressive symptoms and the severity of depression, which should be paid attention to in clinic.

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