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    刘玉侠, 李兴武, 沈芷馨, 张凡, 程佩萍. 血清Cr、hs-CRP、Cys-C、SOD水平变化对急、慢性肾功能衰竭病人的鉴别诊断价值[J]. 蚌埠医科大学学报, 2022, 47(9): 1258-1260. DOI: 10.13898/j.cnki.issn.1000-2200.2022.09.026
    引用本文: 刘玉侠, 李兴武, 沈芷馨, 张凡, 程佩萍. 血清Cr、hs-CRP、Cys-C、SOD水平变化对急、慢性肾功能衰竭病人的鉴别诊断价值[J]. 蚌埠医科大学学报, 2022, 47(9): 1258-1260. DOI: 10.13898/j.cnki.issn.1000-2200.2022.09.026
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    LIU Yu-xia, LI Xing-wu, SEHN Zhi-xin, ZHANG Fan, CHENG Pei-ping. Value of serum Cr, hs-CRP, Cys-C and SOD levels in differential diagnosis of patients with acute and chronic renal failure[J]. Journal of Bengbu Medical University, 2022, 47(9): 1258-1260. DOI: 10.13898/j.cnki.issn.1000-2200.2022.09.026
    Citation: LIU Yu-xia, LI Xing-wu, SEHN Zhi-xin, ZHANG Fan, CHENG Pei-ping. Value of serum Cr, hs-CRP, Cys-C and SOD levels in differential diagnosis of patients with acute and chronic renal failure[J]. Journal of Bengbu Medical University, 2022, 47(9): 1258-1260. DOI: 10.13898/j.cnki.issn.1000-2200.2022.09.026
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    血清Cr、hs-CRP、Cys-C、SOD水平变化对急、慢性肾功能衰竭病人的鉴别诊断价值

    Value of serum Cr, hs-CRP, Cys-C and SOD levels in differential diagnosis of patients with acute and chronic renal failure

      摘要
    • 摘要:
      目的分析血清肌酐(Cr)、超敏CRP(hs-CRP)、胱抑素C(Cys-C)、超氧化物歧化酶(SOD)水平变化对急、慢性肾功能衰竭病人的鉴别诊断价值。
      方法选择83例急慢性肾功能衰竭病人作为研究对象，其中急性肾功能衰竭病人28例，慢性肾功能衰竭病人55例，同期选择健康体检者101名作为对照组；检测受试者血清Cr、hs-CRP、Cys-C、SOD水平，绘制ROC曲线，分析各指标在预测急性和慢性肾功能衰竭病人中的价值。
      结果83例肾功能衰竭病人血清Cr、hs-CRP、Cys-C均明显高于对照组(P < 0.01)，SOD水平明显低于对照组(P < 0.01)；急性肾功能衰竭病人血清中Cr、hs-CRP、Cys-C水平均明显低于慢性肾功能衰竭病人(P < 0.01)，SOD水平明显高于慢性肾功能衰竭病人(P < 0.05)；Cr和Cys-C指标鉴别诊断急性肾功能衰竭和慢性肾功能衰竭的AUC分别为0.73和0.82，有统计学意义(P < 0.01)；hs-CRP和SOD指标鉴别诊断急性和慢性肾功能衰竭AUC分别为0.40和0.38，无统计学意义(P>0.05)。
      结论血清Cr、Cys-C水平测定鉴别诊断急、慢性肾功能衰竭价值明显优于hs-CRP和SOD水平测定。

       

      Abstract:
      ObjectiveTo analyze the value of serum creatinine(Cr), hypersensitive C-reactive protein(hs-CRP), cystatin C(Cys-C), and superoxide dismutase(SOD) levels in the differential diagnosis of patients with acute and chronic renal failure.
      MethodsA total of 83 patients with renal failure were selected as research objects, and 101 healthy subjects were selected as control group in the same period.The levels of serum Cr, hs-CRP, Cys-C and SOD were detected.The ROC curve was drawn, and the value of each index in predicting acute and chronic renal failure was analyzed.
      ResultsThe levels of Cr, hs-CRP and Cys-C in 83 patients with renal failure were significantly higher than those in the control group(P < 0.01), and the level of SOD was significantly lower than that in the control group(P < 0.01).The levels of serum Cr, hs-CRP and Cys-C in patients with acute renal failure were significantly lower than those in patients with chronic renal failure(P < 0.01), and the level of SOD was significantly higher than that in patients with chronic renal failure(P < 0.05).The AUC of Cr and Cys-C in the differential diagnosis of acute and chronic renal failure was 0.73 and 0.82, respectively, the difference of which was statistically significan(P < 0.01).The AUC of hs-CRP and SOD in differential diagnosis of acute and chronic renal failure was 0.40 and 0.38, respectively, the difference of which was not statistically significance(P>0.05).
      ConclusionsThe value of serum Cr and Cys-C levels in differential diagnosis of acute and chronic renal failure was significantly better than that of hs-CRP and SOD levels.

       

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